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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
It is demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection.
Microtubule polymerization dynamics.
This review describes progress toward understanding the mechanism of dynamic instability of pure tubulin and discusses the function and regulation of microtubule dynamic instability in living cells.
Dynamic instability of microtubule growth
We report here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently. This dynamic instability is a general property of microtubules and may…
A chemical method for fast and sensitive detection of DNA synthesis in vivo
- A. Salic, T. Mitchison
- Biology, ChemistryProceedings of the National Academy of Sciences
- 19 February 2008
The method does not require sample fixation or DNA denaturation and permits good structural preservation, and the small size of the fluorescent azides used for detection results in a high degree of specimen penetration, allowing the staining of whole-mount preparations of large tissue and organ explants.
Self- and actin-templated assembly of Mammalian septins.
Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor
It is shown that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis and continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components.
Kin I Kinesins Are Microtubule-Destabilizing Enzymes
Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils
Reassembly of contractile actin cortex in cell blebs
The Rho pathway was important for cortex assembly in blebs, and Ezrin played no role in actin nucleation, but was essential for tethering the membrane to the cortex.
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
This work reveals a sustained rise in H2O2 concentration at the wound margin, and shows that this gradient is created by dual oxidase (Duox), and that it is required for rapid recruitment of leukocytes to the wound.