FAQ

DNM2 protein, human

Known as: Dynamin-2, EC 3.6.5.5, dynamin 2, human 
Dynamin-2 (870 aa, ~98 kDa) is encoded by the human DNM2 gene. This protein plays a role in both microtubule polymerization and GTP hydrolysis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Related topics

Related topics

19 relations
Cell Cycle ProgressionCytoskeletal ModelingCytoskeletonDNM2 gene
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Broader (2)

Dynamin 2Dynamin GTPase

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
DNM2 protein, human
Microtubules
Cytoskeleton
Endocytosis
Microtubule-Associated Proteins
Cell Cycle Progression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Dynamin-2 (Dyn2) is implicated in endocytosis of receptor tyrosine kinases, which contribute to hepatic stellate cell (HSC… (More)
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2016
2016
Multiple Dynamin family members collaborate to drive mitochondrial division
Mitochondria cannot be generated de novo; they must grow, replicate their genome, and divide in order to be inherited by each… (More)
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2016
2016
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia
Dynamin-2 (DNM2) is a GTPase essential for intracellular vesicle formation and trafficking, cytokinesis and receptor endocytosis… (More)
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2014
2014
Clinical, pathological, and genetic features of dynamin-2-related centronuclear myopathy in China
Mutations in the dynamin-2 (DNM2) gene can cause autosomal dominant or sporadic centronuclear myopathy (CNM). We aimed to analyze… (More)
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2010
2010
Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy.
Mutations in dynamin-2 (DNM2) cause autosomal dominant centronuclear myopathy (CNM). We report a series of 12 patients from eight… (More)
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2010
2010
Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation.
K.G. Claeys, MD, PhD T. Maisonobe, MD J. Böhm, PhD J. Laporte, PhD M. Hezode, MD N.B. Romero, MD, PhD G. Brochier M. Bitoun, PhD… (More)
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2010
2010
Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?
The large GTPase dynamin is strongly accumulated in the constricted area including midzonal microtubules of dividing cells. The… (More)
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2008
2008
Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2.
The LOX-1 scavenger receptor recognises pro-atherogenic oxidised low-density lipoprotein (OxLDL) particles and is implicated in… (More)
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2007
2007
Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
BACKGROUND Recently, mutations affecting different domains of dynamin-2 (DNM2) were associated alternatively with autosomal… (More)
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2004
2004
Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
BACKGROUND On exposure to oxidized low-density lipoprotein (oxLDL), vascular cells generally undergo apoptosis, which is one of… (More)
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