2-methoxyestradiol

Known as: 2-Methoxy Estradiol, 2-MeE2, 2 methoxyestradiol 
An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2017
05010015019592017

Papers overview

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Highly Cited
2003
Highly Cited
2003
Bcl-xL, a close homolog of Bcl2, is an important regulator of apoptosis and is overexpressed in human cancer. Phosphorylation of… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol (2ME2) is a novel antitumor and… (More)
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Highly Cited
2002
Highly Cited
2002
2-Methoxyestradiol (2ME(2)) is an endogenous metabolite of 17beta-estradiol (E(2)) that arises from the hydroxylation and… (More)
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2002
2002
2-Methoxyestradiol (2ME2) an estrogen derivative, induces growth arrest and apoptosis in leukemic cells and is also… (More)
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Highly Cited
2001
Highly Cited
2001
Numerous chemotherapeutic agents have been shown to have an inhibitory effect on endothelial cell proliferation and migration… (More)
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Highly Cited
1997
Highly Cited
1997
2-Methoxyestradiol (2-ME), an endogenous estrogen metabolite which disrupts microtubule function, has been shown to inhibit… (More)
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Highly Cited
1997
Highly Cited
1997
2-Methoxyestradiol (2-ME) is an endogenous metabolite of estradiol-17beta and the oral contraceptive agent 17-ethylestradiol. 2… (More)
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1996
1996
The endogenous estrogen metabolite 2-methoxyestradiol (2-MeOE2) suppresses experimental tumor growth in vivo and inhibits… (More)
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Highly Cited
1994
Highly Cited
1994
A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay… (More)
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Highly Cited
1994
Highly Cited
1994
THE formation of new blood vessels (angiogenesis) is critical for the growth of tumours1–3 and is a dominant feature in various… (More)
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