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safingol

Known as: L-threo-2-Amino-1,3-octadecanediol, 2-aminooctadecane-1,3-diol, (2S,3S)-2-Amino-1,3-Octadecanediol 
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (3)

Enzyme InhibitorsSphingosinesphinganine
NCIt Antineoplastic Agent TerminologyPositive Regulation of ApoptosisProtein Kinase Canalogs & derivatives

Narrower (2)

SPC 100270dihydrosphingosine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
syn- and enantioselective Henry reactions of aliphatic aldehydes and application to the synthesis of safingol.
Fundamental Research Funds for the Central Universities [2010121014]; Natural Science Foundation of Fujian Province [2013J10011] 
2010
2010
Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake
2009
2009
The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.
Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been… 
2009
2009
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G
The protein kinase C (PKC) inhibitor safingol increased rounding and detachment of human oral squamous cell carcinoma (SCC) cells… 
2006
2006
Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol
PKC inhibitor safingol suppressed the growth of human oral squamous cell carcinoma (SCC) cells significantly at concentrations… 
2003
2003
Metabolism of the unnatural anticancer lipid safingol, l-threo-dihydrosphingosine, in cultured cells Published, JLR Papers in Press, June 1, 2003. DOI 10.1194/jlr.M300160-JLR200
We studied the metabolism of radioactively labeled safingol (l-threo-dihydrosphingosine) in primary cultured neurons, B104… 
2002
2002
Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines
Protein kinase C (PKC) plays a pivotal role in signal transduction involved in the control of cell proliferation, differentiation… 
Review
2001
Review
2001
Modulation of protein kinase C in antitumor treatment.
PKC isoenzymes were found to be involved in proliferation, antitumor drug resistance and apoptosis. Therefore, it has been tried… 
Highly Cited
2000
Highly Cited
2000
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis
Purpose: Cyclooxygenase-2 (COX-2) is involved in antiapoptosis signaling, and its induction may require activation of protein… 
Highly Cited
1995
Highly Cited
1995
Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase C (*)
Safingol is a lysosphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding… 
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