safingol

Known as: L-threo-2-Amino-1,3-octadecanediol, 2-aminooctadecane-1,3-diol, (2S,3S)-2-Amino-1,3-Octadecanediol 
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
0519952017

Papers overview

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2011
2011
PURPOSE Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is… (More)
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2011
2011
Safingol is a sphingolipid with promising anticancer potential, which is currently in phase I clinical trial. Yet, the underlying… (More)
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2009
2009
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and… (More)
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2007
2007
Safingol [(2S,3S)-2-amino-1,3-octadecanediol] is an unnatural l-threo-stereoisomer of sphinganine that is cytotoxic for cancer… (More)
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2005
2005
PKC inhibitor safingol suppressed the growth of human oral squamous cell carcinoma (SCC) cells significantly at concentrations… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND We previously reported that N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) treatment caused large increases of… (More)
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1997
1997
We performed a pilot clinical trial with safingol (L-threo-dihydrosphingosine), a protein kinase C-specific inhibitor that… (More)
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1995
1995
Safingol [(2S,3S)-2-amino-1,3-octadecanediol] potentiates the toxicity of doxorubicin (DOX) and cisplatin (CIS) against tumor… (More)
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1995
1995
BACKGROUND Protein kinase C (PKC) is a family of enzymes that function in processes relevant to carcinogenesis, tumor cell… (More)
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1995
1995
Safingol is a lysosphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding… (More)
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