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safingol

Known as: L-threo-2-Amino-1,3-octadecanediol, 2-aminooctadecane-1,3-diol, (2S,3S)-2-Amino-1,3-Octadecanediol 
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (3)

Enzyme InhibitorsSphingosinesphinganine
NCIt Antineoplastic Agent TerminologyPositive Regulation of ApoptosisProtein Kinase Canalogs & derivatives

Narrower (2)

SPC 100270dihydrosphingosine

Papers overview

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2017
2017
Abstract 1057: Co-treatment with fenretinide and safingol induced p38 MAPK and/or FOXO3a activated pro-survival autophagy in glioblastoma multiforme cells
2016
2016
Abstract 4656: ER stress, unfolded protein response, and autophagy are pro-survival responses to fenretinide + safingol treatment in GBM cells
2011
2011
SYNTHETIC APPROACHES TO BIOLOGICALLY ACTIVE ALKALOIDS(-)-ISORETRONECANOL, (-)-TRACHELANTHAMIDINE(-)-TASHIROMINE, (-)-5-EPI-TASHIROMINE,(+)-(2R,3R,4R)-DEACETYLANISOMYCIN, (+)-L-733,060 AND SAFINGOL
2005
2005
A practical synthesis of L-threo-dihydrosphingosine (safingol), an antineoplastic and antipsoriatic agent
LS-threo-Dihydrosphingosine, an antineoplastic and antipsoriatic drug, has been synthesized by the Henri reaction of hexadecanal… 
2004
2004
Uptake and metabolism of safingol in human neuroblastoma and leukemia cell lines
2980 We reported that safingol (L-threo-dihydrosphingosine), the isomer of dihydrosphingosine, synergized multi-log fenretinide(4… 
2004
2004
A stable pharmaceutical composition with safingol and method of use