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Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
The enzyme DT-diaphorase (DTD; NAD(P)H:quinone oxidoreductase, EC 1.6.99.2), is an obligate two electron reductase which catalyzes reduction of a broad range of substrates, including quinones. WeExpand
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c-erbB-2 expression in benign and malignant breast disease.
An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffinExpand
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Rat monoclonal antibodies to the external domain of the product of the C‐erbB‐2 proto‐oncogene
With the breast carcinoma cell line BT 474 used as a source of antigen, four rat monoclonal antibodies (MAbs) (3 lgG2a and I IgA) have been prepared against the external domain of the product of theExpand
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Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents.
Safingol [(2S,3S)-2-amino-1,3-octadecanediol] potentiates the toxicity of doxorubicin (DOX) and cisplatin (CIS) against tumor cells in vitro and in vivo. The present studies were conducted in ratsExpand
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Hematology and clinical chemistry reference values for C57BL/6 X DBA/2 F1 mice.
We have analyzed hematology data from 504 individual male C57BL/6 X DBA/2 (hereafter called B6D2F1) mice. Clinical chemistry data from an additional 304 individual male B6D2F1 mice have also beenExpand
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A very early induction of major vault protein accompanied by increased drug resistance in U‐937 cells
U‐937 human leukemia cells were selected for resistance to doxorubicin in the presence or absence of a specific drug modulator that inhibits the activity of P‐glycoprotein (Pgp), encoded by theExpand
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Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere®)
SummaryDocetaxel (Taxotere®, RP 56976, NSC 628503), a new taxoid, was evaluated for preclinical evidence of anticancer activity in athymic nude (NCr-nu) mice bearing established, subcutaneouslyExpand
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Preclinical antitumor activity of batracylin (NSC 320846)
SummaryBatracylin (NSC 320846, BAY H 2049), given ip on days 2 and 9 at a dose of 400 mg/kg, inhibited tumor growth completely in 80–100% of mice with early-stage colon adenocarcinoma 38. TherapeuticExpand
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Immunohistochemical distribution of c‐erbB‐2 in infiltrating and in situ breast cancer
An immunohistochemical study of c‐erbB‐2 expression was performed on invasive and in situ breast cancer. Strong membrane staining was seen in 16% of the infiltrating ductal carcinomas and 44% of theExpand
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Correlation of metal toxicity with in vitro calmodulin inhibition.
  • J. Cox, S. Harrison
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 30 August 1983
A fundamental biochemical process that is directly and universally related to the toxicity of metals and metal compounds has yet to be identified. Results of studies reported here indicate that theExpand
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