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Protein Kinase C

Known as: Phospholipid-Sensitive Calcium-Dependent Protein Kinase, Calcium Phospholipid-Dependent Protein Kinase, PKC 
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional… 
National Institutes of Health

Related topics

Related topics

44 relations
7-hydroxystaurosporineBiological MarkersIn BloodPRKCA protein, human

Narrower (21)

Apl II protein kinase CDKF-2 protein, C elegansPKCA protein, Aspergillus nigerPKN1 protein, human

Broader (1)

Protein Kinases

Papers overview

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Highly Cited
2002
Highly Cited
2002
FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
Highly Cited
2000
Highly Cited
2000
Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress*
Protein kinase C (PKC) isoforms are phosphorylated on tyrosine in the response of cells to oxidative stress. The present studies… 
Highly Cited
1995
Highly Cited
1995
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases (*)
The p53 tumor suppressor protein is a transcription factor with sequence-specific DNA binding activity that is thought to be… 
Highly Cited
1992
Highly Cited
1992
Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.
Highly Cited
1992
Highly Cited
1992
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Highly Cited
1990
Highly Cited
1990
Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II.
Phosphorylation of connexin 32, the major liver gap-junction protein, was studied in purified liver gap junctions and in… 
Highly Cited
1990
Highly Cited
1990
Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression
By using a retrovirus-derived vector system, we generated derivatives of the human colon cancer cell line HT29 that stably… 
Highly Cited
1989
Highly Cited
1989
Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C.
We have evaluated the possibility that a major, abundant cellular substrate for protein kinase C might be a calmodulin-binding… 
Highly Cited
1985
Highly Cited
1985
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters
The activation of protein kinase C by diacylglycerol and by tumour promoters has implicated this enzyme in transmembrane… 
Highly Cited
1984
Highly Cited
1984
A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase.
Arachidonate and other unsaturated long-chain fatty acids were found to activate protein kinase C from human neutrophils. Kinase… 
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