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Protein Kinase C

Known as: Phospholipid-Sensitive Calcium-Dependent Protein Kinase, Calcium Phospholipid-Dependent Protein Kinase, PKC 
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional… 
National Institutes of Health

Related topics

Related topics

44 relations
7-hydroxystaurosporineBiological MarkersIn BloodPRKCA protein, human

Narrower (21)

Apl II protein kinase CDKF-2 protein, C elegansPKCA protein, Aspergillus nigerPKN1 protein, human

Broader (1)

Protein Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Protein kinase C, an elusive therapeutic target?
Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first identified as the receptor for… 
Highly Cited
2008
Highly Cited
2008
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
The target of rapamycin (TOR), as part of the rapamycin‐sensitive TOR complex 1 (TORC1), regulates various aspects of protein… 
Highly Cited
2000
Highly Cited
2000
Induction of vanilloid receptor channel activity by protein kinase C
Capsaicin or vanilloid receptors (VRs) participate in the sensation of thermal and inflammatory pain. The cloned (VR1) and native… 
Review
2000
Review
2000
Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C
Abstract— Voltage-dependent L-type Ca2+ channels are multisubunit transmembrane proteins, which allow the influx of Ca2+ (ICa… 
Highly Cited
1999
Highly Cited
1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
KDR/Flk-1 tyrosine kinase, one of the two VEGF receptors induces mitogenesis and differentiation of vascular endothelial cells… 
Highly Cited
1997
Highly Cited
1997
Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes*
Protein kinase C (PKC) family members play significant roles in a variety of intracellular signal transduction processes, but… 
Highly Cited
1997
Highly Cited
1997
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic…
Induction of protein kinase C (PKC) pathway in the vascular tissues by hyperglycemia has been associated with many of the… 
Highly Cited
1996
Highly Cited
1996
Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf*
Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has… 
Highly Cited
1987
Highly Cited
1987
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.
The regulatory domain of protein kinase C contains an amino acid sequence between residues 19 and 36 that resembles a substrate… 
Highly Cited
1986
Highly Cited
1986
[The role of protein kinase C in cell surface signal transduction and tumor promotion].
Information from certain extracellular signals, including a group of peptide hormones, some neurotransmitters and many other… 
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