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Protein Kinase C

Known as: Phospholipid-Sensitive Calcium-Dependent Protein Kinase, Calcium Phospholipid-Dependent Protein Kinase, PKC 
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional… 
National Institutes of Health

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7-hydroxystaurosporineBiological MarkersIn BloodPRKCA protein, human

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Apl II protein kinase CDKF-2 protein, C elegansPKCA protein, Aspergillus nigerPKN1 protein, human

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Protein Kinases

Papers overview

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2003
2003
Ischemia-Induced Translocation of Protein Kinase C-ε Mediates Cardioprotection in the Streptozotocin-Induced Diabetic Rat
The present study investigated the role of translocation of protein kinase C (PKC) during ischemia/reperfusion in… 
1995
1995
Regulation of cell cycle and apoptosis by protein kinase C in rat myeloid leukemia cell line.
The role of protein kinase C (PKC) in regulation of the cell cycle and induction of apoptosis was examined in a rat myeloid… 
Highly Cited
1987
Highly Cited
1987
Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation.
The role of substrate in influencing the cofactor requirements of the phospholipid- and Ca2+-dependent protein kinase C (PKC) was… 
Highly Cited
1987
Highly Cited
1987
Identification of a Major Defect in Insulin-Resistant Tissues of Genetically Obese (fa/fa) Rats: Impaired Protein Kinase C
In perfused lean rat hearts, the activator of protein kinase C phorbol myristate acetate (PMA), when present alone, stimulates… 
1987
1987
Protein kinase C activation blocks anti-IgM-mediated signaling BAL17 B lymphoma cells.
Short term pretreatment of the B lymphoma, BAL17, with phorbol 12-myristate, 13-acetate (PMA) blocks elevation in inositol… 
Highly Cited
1986
Highly Cited
1986
Rapid assay of binding of tumor-promoting phorbol esters to protein kinase C1.
Protein kinase C is generally accepted to be a receptor protein of tumor-promoting phorbol esters. The binding of [3H]phorbol-12… 
1986
1986
Activation of protein kinase C potentiates norepinephrine release from sinus node.
Localization of binding sites of [20-3H]phorbol-12,13-dibutyrate [( 3H]PDBu) and the involvement of Ca2+-phospholipid-dependent… 
1986
1986
Formation of a phorbol ester-binding fragment from protein kinase C by proteolytic digestion.
When washed human platelets were disrupted by sonication in the presence of ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N… 
Highly Cited
1986
Highly Cited
1986
Gonadotropin-releasing hormone (GnRH) rapidly stimulates the formation of inositol phosphates and diacyglycerol in rat granulosa cells: further evidence for the involvement of Ca2+ and protein kinase…
GnRH provokes a phospholipid response in rat granulosa cells that has been characterized by increased incorporation of… 
Highly Cited
1986
Highly Cited
1986
An inhibitory role for polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets.
The occurrence and function of polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets were…