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Self-formation of functional adenohypophysis in three-dimensional culture
TLDR
Efficient self-formation of three-dimensional adenohypophysis tissues in an aggregate culture of mouse embryonic stem (ES) cells is reported, indicating functional anterior pituitary tissue self-forms in ES cell culture, recapitulating local tissue interactions. Expand
Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion.
TLDR
In vitro examination showed the percentage of osteoblastic cells undergoing apoptosis to be significantly decreased in the presence of GIP, indicating that GIPR(-/-) mice have high-turnover osteoporosis. Expand
Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats
TLDR
The results suggest that MSC transplantation could have therapeutic effects on DPN through paracrine actions of growth factors secreted by MSCs. Expand
Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice
TLDR
Findings indicate that exendin-4 ameliorates the severity of DPN, which may be achieved by its direct actions on DRG neurons and their axons. Expand
Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion*
TLDR
The regulation of actin dynamics by neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin in pancreatic β-cells determines the biphasic glucose-induced insulin secretion (GIIS). Expand
Isx Participates in the Maintenance of Vitamin A Metabolism by Regulation of β-Carotene 15,15′-Monooxygenase (Bcmo1) Expression*
TLDR
Data suggest that Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine. Expand
Enhanced Expression of the Inorganic Phosphate Transporter Pit‐1 Is Involved in BMP‐2–Induced Matrix Mineralization in Osteoblast‐Like Cells
TLDR
Experimental analysis suggest that this response in BMP‐2 enhances Pit‐1 Pi transporters in osteogenic cells is required for bone matrix calcification. Expand
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
TLDR
It is found that anterior pituitary self-forms in vitro following the co-induction of hypothalamic and oral ectoderm, and after transplantation into hypopituitary mice, the in vitro-generated corticotrophs rescued physical activity levels and survival of the hosts. Expand
The role of S100B in the interaction between adipocytes and macrophages
TLDR
The S100 calcium binding protein B implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes, which results in the interaction between adipocytes and macrophages using a cell‐culture model. Expand
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes.
TLDR
It is suggested that insulin downregulates angptl4 mRNA expression via PI3K/Foxo1 pathway in 3T3-L1 adipocytes, and that the reduction of angptL4 mRNA by insulin is attenuated in insulin resistance. Expand
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