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sphinganine

Known as: 2-Amino-1,3-Dihydroxyoctadecane, L-Threo-Dihydrosphingosine 
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), L-threo-dihydrosphingosine competitively binds to the regulatory… 
National Institutes of Health

Related topics

Related topics

3 relations
SPC 100270dihydrosphingosine

Broader (1)

safingol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.
Highly Cited
2000
Highly Cited
2000
Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform*
Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a second messenger to regulate… 
Highly Cited
1998
Highly Cited
1998
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase*
Sphingosine-1-phosphate (SPP) is a novel lipid messenger that has dual function. Intracellularly it regulates proliferation and… 
Review
1996
Review
1996
Fumonisins, mycotoxins of increasing importance: their nature and their effects.
Highly Cited
1995
Highly Cited
1995
The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity.
Potent antifungal activity was detected in fermentation extracts of Sporormiella australis and two related components were… 
Highly Cited
1994
Highly Cited
1994
Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.
Highly Cited
1993
Highly Cited
1993
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
Highly Cited
1992
Highly Cited
1992
Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme.
Consumption of food contaminated with Fusarium moniliforme causes leucoencephalomalacia and hepatotoxicity in horses, pulmonary… 
Highly Cited
1992
Highly Cited
1992
Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells.
Highly Cited
1988
Highly Cited
1988
Quantitation of free sphingosine in liver by high-performance liquid chromatography.
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