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Effect of androgen deficiency on the human meibomian gland and ocular surface.
TLDR
The results demonstrate that patients taking antiandrogen treatment had a significant increase in the frequency of appearance of tear film debris, an abnormal tear film meniscus, irregular posterior lid margins, conjunctival tarsal injection, and orifice metaplasia of the meibomian glands. Expand
Androgen influence on the meibomian gland.
TLDR
The findings show that the meibomian gland is an androgen target organ and that androgens influence the lipid profile within this tissue, however, the extent to which androgens regulate the production of these lipids and whether this action may impact tear film stability remain to be determined. Expand
Proteomic analysis of human meibomian gland secretions
TLDR
These findings indicate that the meibomian gland secretes a number of proteins into the tear film in both health and disease. Expand
Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy.
TLDR
The structure of the major antigenic glycolipid from human peripheral nerve was determined by chemical and enzymatic degradation, incorporation studies, sugar analysis after permethylation, pertrimethylsilylation, and gas liquid chromatography-mass spectrometry techniques as well as fast atom bombardment-mass Spectrometry of the native antigen. Expand
Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus.
TLDR
The occurrence of a mutation in ts1C inducing substitution of a phenylalanine for a serine residue at an adjacent site (731) suggests that mutations in this region of the polymerase can have significant attenuating effects, and the data suggest also that a mutations in the F gene may contribute to the attenuated phenotype. Expand
Embryonic and postnatal expression of four gamma‐aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges
TLDR
Although mGATs 1 and 4 may subserve the classical purpose of terminating inhibitory GABAergic transmission through neuronal and glial uptake mechanisms, GABA transporters in the pia‐arachnoid may help to regulate the amount of GABA available to proliferating and migrating neurons at the sub‐pial surface during perinatal development. Expand
A GC/MS/MS screening method for multiple organic acidemias from urine specimens.
TLDR
The method, with its relatively fast sample preparation, short 10.0 min run time and simple data analysis, is suitable for use as a quick metabolic screen of very sick patients in whom there is concern regarding the possibility of a treatable inborn error. Expand
Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions.
TLDR
Results demonstrate that antiandrogen therapy is associated with significant and consistent alterations in the mass/charge ratios of neutral lipid fractions of meibomian gland secretions. Expand
Studies With Stable Isotopes II: Phenobarbital Pharmacokinetics During Monotherapy
TLDR
Six healthy adults receiving no other medications were given tracer doses of 90 mg of stable isotope‐labeled phenobarbital intravenously before, and four weeks after, and 12 weeks after beginning therapy, and clearances determined from single‐dose studies before beginning PB therapy accurately predicted steady‐state PB serum concentrations. Expand
Expression and characterisation of the NS1 and NS2 proteins of respiratory syncytial virus.
TLDR
The results indicate that the NS1 and NS2 proteins have distinct roles in the viral life cycle and could be co-precipitated by a monoclonal antibody to M protein. Expand
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