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pyrrophenone

National Institutes of Health

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Broader (2)

Phospholipase A2 InhibitorsPyrrolidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The role of cPLA2 in Methylglyoxal‐induced cell apoptosis of HUVECs
Highly Cited
2015
Highly Cited
2015
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
BackgroundOxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological… 
2012
2012
HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)α dependent PGE(2)via both PKA and PKB pathways.
Highly Cited
2007
Highly Cited
2007
TLR3-Dependent Induction of Nitric Oxide Synthase in RAW 264.7 Macrophage-Like Cells via a Cytosolic Phospholipase A2/Cyclooxygenase-2 Pathway1
dsRNA is a by-product of viral replication capable of inducing an inflammatory response when recognized by phagocyte cells. In… 
Highly Cited
2006
Highly Cited
2006
Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
2006
2006
Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils
The biosynthesis of leukotrienes (LT) and platelet‐activating factor (PAF) involves the release of their respective precursors… 
2005
2005
Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide.
2005
2005
Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha.
Highly Cited
2003
Highly Cited
2003
Amplification Mechanisms of Inflammation: Paracrine Stimulation of Arachidonic Acid Mobilization by Secreted Phospholipase A2 Is Regulated by Cytosolic Phospholipase A2-Derived…
In macrophages and other major immunoinflammatory cells, two phospholipase A2 (PLA2) enzymes act in concert to mobilize… 
Highly Cited
2002
Highly Cited
2002
Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha), one of the three subtypes of cPLA(2) (alpha, beta and gamma), is thought to be… 
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