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The phospholipase A2 superfamily and its group numbering system.
The superfamily of phospholipase A(2) (PLA(2)) enzymes currently consists of 15 Groups and many subgroups and includes five distinct types of enzymes, namely the secreted PLA(2)s (sPLA(2)), the… Expand
The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
The phospholipase A(2) (PLA(2)) superfamily consists of a broad range of enzymes defined by their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate phospholipids. The… Expand
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.
- E. Dennis, J. Cao, Y. Hsu, V. Magrioti, G. Kokotos
- Chemistry, Medicine
- Chemical reviews
- 12 October 2011
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the earliest enzyme activities to be identified and studied and the phospholipase A2 (PLA2) superfamily (see… Expand
A comprehensive classification system for lipids11 The evaluation of this manuscript was handled by the former Editor-in-Chief Trudy Forte. Published, JLR Papers in Press, February 16, 2005. DOI…
Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, “lipidomics,” in the… Expand
LMSD: LIPID MAPS structure database
- M. Sud, E. Fahy, +8 authors S. Subramaniam
- Computer Science, Biology
- Nucleic Acids Res.
- 10 November 2006
The LIPID MAPS Structure Database (LMSD) is a relational database encompassing structures and annotations of biologically relevant lipids. Expand
Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]
- O. Quehenberger, A. Armando, +21 authors E. Dennis
- Biology, Medicine
- Journal of Lipid Research
- 1 November 2010
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a… Expand
Eicosanoid storm in infection and inflammation
Controlled immune responses to infection and injury involve complex molecular signalling networks with coordinated and often opposing actions. Eicosanoids and related bioactive lipid mediators… Expand
Inhibition of Macrophage Ca-independent Phospholipase A by Bromoenol Lactone and Trifluoromethyl Ketones (*)
- E. J. Ackermann, K. Conde-Frieboes, E. Dennis
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 6 January 1995
A novel Ca-independent phospholipase A2 (PLA2) has recently been purified from the murine macrophage-like cell line P388D1 (Ackermann, E. J., Kempner, E. S., and Dennis, E. A.(1994) J. Biol. Chem.… Expand
Diversity of group types, regulation, and function of phospholipase A2.
- E. Dennis
- Medicine, Chemistry
- The Journal of biological chemistry
- 6 May 1994
Phospholipase A2 regulation of arachidonic acid mobilization
Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes, and to date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has attracted considerable… Expand