Regulatory mechanism and physiological role of cytosolic phospholipase A2.
- T. Hirabayashi, T. Murayama, Takao Shimizu
- BiologyBiological and Pharmaceutical Bulletin
- 1 August 2004
This review discusses the essential features of cPLA2alpha regulation and addresses new insights into the functional properties of this enzyme, which has been implicated in fertility, striated muscle growth, renal concentration, postischemic brain injury, arthritis, inflammatory bone resorption, intestinal polyposis, pulmonary fibrosis, acute respiratory distress syndrome, and autoimmune encephalomyelitis.
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
- Kenjiro Matsumoto, S. Horie, Kazuo Watanabe
- Biology, ChemistryLife Science
- 19 November 2005
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
- Kenjiro Matsumoto, Y. Hatori, S. Horie
- Biology, MedicineEuropean Journal of Pharmacology
- 7 November 2006
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
- H. Yamamoto, S. Horie, M. Uchida, S. Tsuchiya, T. Murayama, K. Watanabe
- Medicine, BiologyEuropean Journal of Pharmacology
- 7 December 2001
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice
- Kenjiro Matsumoto, Mee Wah Lo, S. Horie
- BiologyLaboratory Investigation
- 1 May 2012
The novel observation of increased expression of neuronal/nonneuronal TRPV1 channels and 5-HT3 receptors, and decreased expression of5-HT4 receptors in the mucosa in a DSS-induced colitis model mice is made, which may contribute to the visceral hypersensitivity in colitismodel mice.
Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8.
Increases in expression of proinflammatory cytokines in the brain may be involved in the age-related neural dysfunction and/or learning deficiency in SAMP8.
Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
- T. Murayama, M. Ui
- Biology, ChemistryJournal of Biological Chemistry
- 10 March 1983
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
- H. Takayama, H. Ishikawa, S. Horie
- Biology, ChemistryJournal of Medicinal Chemistry
- 20 March 2002
The oxidative derivatives of mitragynine were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum, and 2 induced an analgesic activity in the tail flick test in mice.
TRPM8 has a key role in experimental colitis‐induced visceral hyperalgesia in mice
- T. Hosoya, K. Matsumoto, S. Horie
- BiologyNeurogastroenterology and Motility
- 1 August 2014
This work investigated the distribution of TRPM8 and its involvement in visceral hyperalgesia in experimental colitis mice and found it to be poorly understood in pathological states such as inflammatory bowel disease.
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