T. Murayama

Publications224
h-index33
Citations4,518
Highly Influential Citations102
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Regulatory mechanism and physiological role of cytosolic phospholipase A2.
TLDR
This review discusses the essential features of cPLA2alpha regulation and addresses new insights into the functional properties of this enzyme, which has been implicated in fertility, striated muscle growth, renal concentration, postischemic brain injury, arthritis, inflammatory bone resorption, intestinal polyposis, pulmonary fibrosis, acute respiratory distress syndrome, and autoimmune encephalomyelitis. Expand
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
TLDR
7-Hydroxymitragynine exhibited a potent antinociceptive effect based on activation of mu-opioid receptors and its morphine-like pharmacological character, but 7-hydroxymitagynine is structurally different from morphine. Expand
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
TLDR
The results suggest that mu-opioid receptor mechanisms mediate the antinociceptive effect and inhibition of gastrointestinal transit of 7-hydroxymitragynine, and that this compound induced more potent antinOCiceptive effects and was less constipating than morphine. Expand
Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
  • T. Murayama, M. Ui
  • Medicine, Biology
  • The Journal of biological chemistry
  • 10 March 1983
TLDR
The conclusion is that the sole site of IAP action is the guanine nucleotide regulatory protein (Ni) that is required for transmission of inhibitory signals from receptors to the catalytic unit of adenylate cyclase; the function of Ni is lost upon IAP-catalyzed ADP ribosylation of the Mr = 41,000 protein which appears to be an active subunit of Ni. Expand
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
TLDR
The oxidative derivatives of mitragynine were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum, and 2 induced an analgesic activity in the tail flick test in mice. Expand
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
TLDR
The results suggest that vanilloid receptors play a gastroprotective role in gastric antral ulcers and treatment with ruthenium red may be an alternative tool for defunctionalization of capsaicin-sensitive afferent nerves. Expand
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice
TLDR
The novel observation of increased expression of neuronal/nonneuronal TRPV1 channels and 5-HT3 receptors, and decreased expression of5-HT4 receptors in the mucosa in a DSS-induced colitis model mice is made, which may contribute to the visceral hypersensitivity in colitismodel mice. Expand
Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8.
TLDR
Increases in expression of proinflammatory cytokines in the brain may be involved in the age-related neural dysfunction and/or learning deficiency in SAMP8. Expand
Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.
  • T. Murayama, M. Ui
  • Medicine, Biology
  • The Journal of biological chemistry
  • 25 April 1987
TLDR
It is proposed that PA interacts with its own specific membrane receptors, thereby triggering multiple effector systems in 3T3 cells, and mediated by an islet-activating protein substrate GTP-binding protein. Expand
Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.
TLDR
The results show the existence of H1 histamine receptors which couple phospholipase A2 activation via pertussis toxin-sensitive G proteins, and Histamine actions differ in sensitivities to anti-beta gamma antiserum treatment and PMA treatment from thrombin actions. Expand
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