Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.

@article{Taniguchi2007VanadateinducedAO,
  title={Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.},
  author={Tomoko Taniguchi and Masaya Shimizu and Hiroyuki Nakamura and Tetsuya Hirabayashi and Hiromichi Fujino and Takeshi Saito and Toshihiko Murayama},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 6},
  pages={
          854-62
        }
}
Orthovanadate (Na3VO4), which acts as an inhibitor of protein tyrosine phosphatases, has a various pharmacological effects including the release of arachidonic acid (AA) from cells. We investigated roles of alpha-type cytosolic phospholipase A2 (cPLA2alpha), Src family kinases (Src) and protein kinase C (PKC) in the release of AA induced by Na3VO4 from a murine fibroblast cell line, L929. C12 cells, a variant of L929 that lacks expression of cPLA2alpha, were used along with a clone of C12 cells… 
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