Phospholipase A2 Inhibitors

Known as: A2 Antagonists, Phospholipase, Phospholipase A2 Antagonists, Antagonists, Phospholipase A2

Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.

National Institutes of Health

Papers overview

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2016

The work examines the effect of inhibitors of cytosolic Ca2+-dependent and Ca2+-independent phospholipases A2 on bilayer lipid…

2008

Secreted phospholipases A2 (sPLA2s) are a family of enzymes which catalyze the hydrolysis of glycophospholipids at the sn-2…

2006

The present invention provides various phospholipase enzymes, particularly cytosolic phospholipase A In some embodiments, the…

1998

Modulation of pro-inflammatory lipid mediator production by inhibition of phospholipase A2 (PLA2) activity remains a potential…

Review

1997

Review

1997

To date, three isoforms of phospholipase A2 (PLA2) have been identified. Of these, the two Ca 2+ -dependent isoforms, secretory…

1994

Mammalian nonpancreatic secretory phospholipase A2 (PLAz) splits the 2-acyl bond in 1,2-diacylpho~phatide.~ This enzyme has been…

1987

1986

p-Bromphenacyl bromide (BPB) at concentrations of 50 microM and above and quinacrine (50 microM) abolished the actions of…

1984

The mechanism of activation of intestinal guanylate cyclase by Escherichia coli heat-stable enterotoxin (STa) has been studied by…