Skip to search formSkip to main contentSkip to account menu

Phospholipase A2 Inhibitors

Known as: A2 Antagonists, Phospholipase, Phospholipase A2 Antagonists, Antagonists, Phospholipase A2 
Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (7)

AX 059PF-5212372darapladibecopladib
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Recent Developments with Lipoprotein-Associated Phospholipase A2 Inhibitors
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 enzyme secreted by leukocytes and… 
2006
2006
Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor.
Mammalian secreted phospholipases A(2) (sPLA(2)s) constitute a family of structurally related enzymes that are likely to play… 
Review
2005
Review
2005
Phospholipase A2 inhibitors as potential anti-inflammatory agents.
Phospholipase A(2) (PLA(2))-catalyzed hydrolysis of membrane phospholipids results in the stoichiometric production of a free… 
2004
2004
Phospholipase A2 Inhibitors or Platelet-activating Factor Antagonists Prevent Prion Replication*
A key feature of prion diseases is the conversion of the cellular prion protein (PrPC) into disease-related isoforms (PrPSc), the… 
1994
1994
Rational modification of human synovial fluid phospholipase A2 inhibitors.
Mammalian nonpancreatic secretory phospholipase A2 (PLAz) splits the 2-acyl bond in 1,2-diacylpho~phatide.~ This enzyme has been… 
Highly Cited
1994
Highly Cited
1994
Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis.
Highly Cited
1989
Highly Cited
1989
Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.
The stimulation of O2.- generation by phorbol 12-myristate 13-acetate (PMA) in human neutrophil-derived cytoplasts was inhibited… 
1989
1989
Ca2+-antagonistic properties of phospholipase A2 inhibitors, mepacrine and chloroquine.
The effects of putative phospholipase A2 inhibitors mepacrine and chloroquine on membrane ionic currents were studied in intact… 
1984
1984
Inhibition of lipid peroxidation in muscle homogenates by phospholipase A2 inhibitors
Chlorpromazine, mepacrine, tetracaine, dibucaine, chloroquine, and procaine have been shown to inhibit the iron- and ascorbate… 
Highly Cited
1979
Highly Cited
1979
Anti‐inflammatory and platelet anti‐aggregant activity of phospholipase‐A2 inhibitors
Mepacrine, papaverine, p‐bromophenacyl bromide and 2,3‐dibromo(4′‐cyclohexyl‐3′‐chloro)‐phenyl‐4‐oxo‐butyric acid (CB 874… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)