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Phospholipase A2 Inhibitors

Known as: A2 Antagonists, Phospholipase, Phospholipase A2 Antagonists, Antagonists, Phospholipase A2 
Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.
National Institutes of Health

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AX 059PF-5212372darapladibecopladib
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2010
2010
Up-regulation of the expressions of phospholipase A2 inhibitors in the liver of a venomous snake by its own venom phospholipase A2.
2005
2005
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2
Human cytosolic phospholipase A2 (cPLA2, 85 kDa) appears to be pharmacologically distinct from human secretory phospholipase A2… 
1998
1998
The therapeutic potential for phospholipase A2 inhibitors
Modulation of pro-inflammatory lipid mediator production by inhibition of phospholipase A2 (PLA2) activity remains a potential… 
Review
1995
Review
1995
Secretory phospholipase A2 inhibitors. Possible new anti-inflammatory agents.
Secretory phospholipase A2 (sPLA2) is now clearly considered to be involved in the pathogenesis of both experimental and clinical… 
1994
1994
Rational modification of human synovial fluid phospholipase A2 inhibitors.
Mammalian nonpancreatic secretory phospholipase A2 (PLAz) splits the 2-acyl bond in 1,2-diacylpho~phatide.~ This enzyme has been… 
Highly Cited
1994
Highly Cited
1994
Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis.
1993
1993
Prostaglandin F2 alpha synthesis in the hippocampal mossy fiber synaptosomal preparation: I. Dependence in arachidonic acid, phospholipase A2, calcium availability and membrane depolarization.
1991
1991
Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells.
1984
1984
Inhibition of lipid peroxidation in muscle homogenates by phospholipase A2 inhibitors
Chlorpromazine, mepacrine, tetracaine, dibucaine, chloroquine, and procaine have been shown to inhibit the iron- and ascorbate… 
Highly Cited
1979
Highly Cited
1979
Anti‐inflammatory and platelet anti‐aggregant activity of phospholipase‐A2 inhibitors
Mepacrine, papaverine, p‐bromophenacyl bromide and 2,3‐dibromo(4′‐cyclohexyl‐3′‐chloro)‐phenyl‐4‐oxo‐butyric acid (CB 874… 
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