Skip to search formSkip to main contentSkip to account menu

darapladib

A substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2), an important regulator of lipid… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

BenzaldehydesOximesPhospholipase A2 Inhibitors

Narrower (1)

SB-480848

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Chronic inhibition of lipoprotein-associated phospholipase A2 does not improve coronary endothelial function: A prospective, randomized-controlled trial.
2015
2015
Lp‐PLA2, Plaque Inflammation and Lesion Development Vary Fundamentally Between Different Vascular Sites
Lp‐PLA2 is also known as platelet activating factor (PAF) acetylhydrolase (PAF‐AH) or PLA2G7, owing to its hierarchical position… 
2013
2013
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).
Review
2013
Review
2013
Targeting the unstable plaque in acute coronary syndromes.
2013
2013
Lp-PLA2--a novel marker of atherosclerosis: to treat or not to treat?
2011
2011
The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice
Aim:To investigate the effects of darapladib, a specific inhibitor of lipoprotein-associated phospholipase A2 (lp-PLA2), on… 
Review
2010
Review
2010
Phospholipase A2s: developing drug targets for atherosclerosis.
Review
2010
Review
2010
Extracellular phospholipases in atherosclerosis.
Review
2010
Review
2010
Lipoprotein-associated phospholipase A2: a new therapeutic target.
Review
2009
Review
2009
Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease.
Darapladib, under development by GlaxoSmithKline plc, is a novel inhibitor of lipoprotein-associated phospholipase A2 (PLA2), an… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)