darapladib

A substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2), an important regulator of lipid… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
IMPORTANCE Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through… (More)
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Review
2014
Review
2014
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the… (More)
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2014
2014
BACKGROUND Elevated lipoprotein-associated phospholipase A2 activity promotes the development of vulnerable atherosclerotic… (More)
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2013
2013
Diabetes mellitus (DM) and hypercholesterolemia (HC) have emerged as major risk factors for Alzheimer's disease, highlighting the… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Higher levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) are associated with a higher risk of… (More)
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2011
2011
OBJECTIVE Subjects with peripheral artery disease (PAD) are at increased risk of cardiovascular morbidity and mortality, perhaps… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Elevated plasma levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) are associated with increased risk of… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is expressed abundantly in the necrotic core of coronary lesions… (More)
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Highly Cited
2008
Highly Cited
2008
Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity is associated with increased risk of cardiac events, but it… (More)
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