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darapladib

A substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2), an important regulator of lipid… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Background Interleukin‐6 (IL‐6) is an inflammatory cytokine implicated in plaque instability in acute coronary syndrome (ACS). We… Expand
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Review
2017
Review
2017
Background It is unknown whether short sleep duration, obstructive sleep apnea, and overnight shift work are associated with the… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Elevated lipoprotein-associated phospholipase A2 activity promotes the development of vulnerable atherosclerotic… Expand
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Highly Cited
2014
Highly Cited
2014
hazard ratio [HR], 1.00 [95% CI, 0.91-1.09]; P = .93). The composite of cardiovascular death, MI, or stroke occurred in 824 in… Expand
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Highly Cited
2014
Highly Cited
2014
IMPORTANCE Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through… Expand
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Review
2014
Review
2014
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Elevated plasma levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) are associated with increased risk of… Expand
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Highly Cited
2008
Highly Cited
2008
Background— Lipoprotein-associated phospholipase A2 (Lp-PLA2) is expressed abundantly in the necrotic core of coronary lesions… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This study examined the effects of darapladib, a selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2… Expand
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Highly Cited
2008
Highly Cited
2008
Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity is associated with increased risk of cardiac events, but it… Expand
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