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darapladib
A substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2), an important regulator of lipid…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Benzaldehydes
Oximes
Phospholipase A2 Inhibitors
Narrower (1)
SB-480848
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The Effect of Darapladib Therapy for the Expression of Lp-PLA 2 in Dyslipidemia and Type 2 Diabetes Mellitus Atherosclerosis Model Titin
A. Wihastuti
,
R. D. Lestari
,
T. Heriansyah
2018
Corpus ID: 13696032
© 2018 Titin Andri Wihastuti et al. This is an open access article distributed under the terms of the Creative Commons…
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2016
2016
Atherogenesis inhibition by darapladib administration in dyslipidemia model Sprague–Dawley rats -
T. Heriansyah
,
T. Wihastuti
,
+4 authors
Lintang Widya Sishartami
2016
Corpus ID: 74340900
Background: Atherosclerosis is a chronic inflammation disease that is caused by the interaction between monocyte and endothelial…
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2016
2016
The Effect of Darapladip on Lipid Profile, Insulin, Ox-LDL Serum Level and PVAT Thickness At Atherogenesis Development in DM Tipe 2 Rats Model
T. Heriansyah
,
B. Siswanto
,
A. Santoso
,
D. Sargowo
2016
Corpus ID: 13672257
Atherosclerosis is a chronic inflammation response of cholesterol deposition in artery vascular wall. The most common risk factor…
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2014
2014
Disposition and Metabolism of Darapladib , a Lipoprotein-Associated Phospholipase A 2 Inhibitor , in Humans
M. Dave
,
M. Nash
,
+6 authors
G. Boyle
2014
Corpus ID: 26694828
The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was…
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2014
2014
Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
A. Act
2014
Corpus ID: 74662022
Background Elevated lipoprotein-associated phospholipase A 2 activity promotes the development of vulnerable atherosclerotic…
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2013
2013
Amelioration of atherosclerosis in apolipoprotein Ede cient mice by inhibition of lipoprotein-associated phospholipase A 2
T. Sun
,
De-Liang Shen
,
Y. Dang
2013
Corpus ID: 2107981
Purpose: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is involved in the pathogenesis of atherosclerosis, especially in…
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Review
2013
Review
2013
[Clinical role of lipoprotein-associated phospholipase A2].
S. V. Miklishanskaia
,
A. A. Liakishev
,
V. Kukharchuk
Kardiologiia
2013
Corpus ID: 24396068
Inflammation plays an important role in origin and progression of atheromatous plaque. Lipoprotein-associated phospholipase A2…
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Review
2012
Review
2012
Novel therapeutic concepts Phospholipase A 2 enzymes and the risk of atherosclerosis
R. Rosenson
,
E. Hurt-Camejo
2012
Corpus ID: 27702697
Certain members of the phospholipase A2 superfamily of enzymes have established causal involvement in atherosclerosis, thus at…
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2010
2010
Darapladib and its potential for plaque stabilization and prevention of cardiac events
H. White
2010
Corpus ID: 73189059
Abstract Darapladib is a novel oral compound that selectively inhibits lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2…
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2007
2007
Abstract 266: Darapladib, A Selective Inhibitor Of Lp-PLA2, Reduces Coronary Atherosclerosis In Diabetic, Hypercholesterolemic Swine
R. Wilensky
,
Yi Shi
,
+8 authors
C. Macphee
2007
Corpus ID: 68174481