Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to…
- Masaya Shimizu, C. Azuma, T. Taniguchi, T. Murayama
- Biology, Computer ScienceJournal of Pharmacological Sciences
Results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha, and the role of Ser505 phosphorylation in AA release induced by PMA is discussed.
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity…
Synthetic phosphorylated lipid analogs may be useful for studying PLA(2) activity and its toxicity in cells, and a high correlation coefficient was observed.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α
Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase A2alpha-independent pathway.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha.
- T. Taniguchi, Masaya Shimizu, Hiroyuki Nakamura, T. Hirabayashi, H. Fujino, T. Murayama
- Biology, Computer ScienceEuropean Journal of Pharmacology
It is suggested that H( 2)O(2) with Ca(2+) stimulates arachidonic acid release via cPLA(2]alpha in a Src- and PKC-dependent manner in L929 cells.