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Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
TLDR
It is proposed that C1P stimulates AA release via two mechanisms; direct activation of cPLA2alpha, and the PKC-dependent pathway. Expand
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.
TLDR
The findings suggest that C1P is a stimulatory factor on cPLA(2)alpha that is independent of the Ca(2+) signal and the PKC-ERK-mediated phosphorylation signal. Expand
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine.
TLDR
It is suggested that ceramide and D-erythro-analogs of sphingosine have opposite effects on phospholipase A2 activity and thus regulate arachidonic acid release from cells. Expand
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
TLDR
Findings show a possible effect of CaM kinase on cPLA(2)alpha in a catalytic domain A-dependent and Ser515-independent manner. Expand
Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to
TLDR
Results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha, and the role of Ser505 phosphorylation in AA release induced by PMA is discussed. Expand
Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity
TLDR
Synthetic phosphorylated lipid analogs may be useful for studying PLA(2) activity and its toxicity in cells, and a high correlation coefficient was observed. Expand
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α
TLDR
It is suggested that H 2 O 2 with Ca 2+ stimulates arachidonic acid release via cPLA 2 α in a Src- and PKC-dependent manner in L929 cells. Expand
Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
TLDR
Roles of alpha-type cytosolic phospholipase A2 (cPLA2alpha), Src family kinases (Src) and protein kinase C (PKC) in the release of AA induced by Na3VO4 from a murine fibroblast cell line, L929, are investigated. Expand
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase A2alpha-independent pathway.
TLDR
TNFalpha/zVAD appears to stimulate release of AA from C12 cells in a cPLA(2)alpha-independent, BHA-sensitive manner and reactive oxygen species from different pools in the release ofAA and cell death were discussed. Expand
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha.
TLDR
It is suggested that H( 2)O(2) with Ca(2+) stimulates arachidonic acid release via cPLA(2]alpha in a Src- and PKC-dependent manner in L929 cells. Expand
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