Skip to search formSkip to main contentSkip to account menu

perforin

Known as: Lymphocyte Pore-Forming Protein, Perforin [Chemical/Ingredient], Cytolysin 
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (2)

CytolysinsCytotoxin
In BloodPRF1 genePRF1 wt AllelePerforin Ag:PrThr:Pt:Tiss:Ord:Immune stain

Narrower (1)

PRF1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
MHC class I‐restricted killing of neurons by virus‐specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
Induction of MHC class I genes in neurons of the central nervous system requires signals by pro‐inflammatory cytokines, in… 
Highly Cited
1999
Highly Cited
1999
Homeostatic regulation of CD8+ T cells by perforin
To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by… 
Highly Cited
1999
Highly Cited
1999
Oligomerization of Vibrio cholerae Cytolysin Yields a Pentameric Pore and Has a Dual Specificity for Cholesterol and Sphingolipids in the Target Membrane*
Vibrio cholerae cytolysin permeabilizes animal cell membranes. Upon binding to the target lipid bilayer, the protein assembles… 
Highly Cited
1998
Highly Cited
1998
Mechanisms of beta cell death in diabetes: a minor role for CD95.
Insulin-dependent diabetes mellitus is an autoimmune disease, under polygenic control, manifested only when >90% of the insulin… 
Highly Cited
1996
Highly Cited
1996
Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.
Lymphokine-activated killer (LAK) cells generated from perforin knockout mice possess significantly reduced cytotoxicity against… 
Highly Cited
1996
Highly Cited
1996
Extending the C2 domain family: C2s in PKCs δ, ϵ,η,θ, phospholipases, GAPs, and perforin
Various membrane lipid metabolites, generated by phospholipases C and D (PLCs, PLDs), are known to regulate the activities of… 
Highly Cited
1994
Highly Cited
1994
Lymphocyte activation in HIV‐1 infection. II. Functional defects of CD28− T cells
Objectives and design:The expression of the accessory molecule CD28 was compared in various populations of T and natural killer… 
Highly Cited
1994
Highly Cited
1994
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
Lymphocyte-mediated cytotoxicity has been proposed to consist of the polarized secretion of granule-stored perforin leading to… 
Highly Cited
1991
Highly Cited
1991
Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme…
Mouse gut intraepithelial lymphocytes (IEL), whether thymodependent (CD4+ or CD8 alpha/beta +; TCR-alpha/beta +) or… 
Highly Cited
1989
Highly Cited
1989
Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
The rapid breakdown of target cell DNA during CTL-mediated lysis has been difficult to explain by the granule exocytosis model of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)