perforin

Known as: Lymphocyte Pore-Forming Protein, Perforin [Chemical/Ingredient], Cytolysin 
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction… (More)

Topic mentions per year

Topic mentions per year

1985-2017
010020019852017

Papers overview

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Highly Cited
2005
Highly Cited
2005
CD4+CD25+ regulatory T cells (Treg) are potent immunosuppressive cells that are pivotal in the regulation of peripheral tolerance… (More)
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Highly Cited
2004
Highly Cited
2004
Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill virally infected cells and tumor cells… (More)
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Highly Cited
2002
Highly Cited
2002
It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8… (More)
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Highly Cited
2000
Highly Cited
2000
Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for decades, but direct evidence for the role of… (More)
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Highly Cited
2000
Highly Cited
2000
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in… (More)
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Highly Cited
1999
Highly Cited
1999
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, rapidly fatal, autosomal recessive immune disorder characterized by… (More)
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Highly Cited
1996
Highly Cited
1996
Immune surveillance against tumors usually depends on T cell recognition of tumor antigens presented by major histocompatibility… (More)
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Highly Cited
1994
Highly Cited
1994
Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CD8+ cytolytic T… (More)
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Highly Cited
1994
Highly Cited
1994
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To… (More)
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Highly Cited
1994
Highly Cited
1994
The recent generation of perforin knock-out mice has demonstrated a crucial role for the pore-forming perforin in cytolytic T… (More)
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