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perforin

Known as: Lymphocyte Pore-Forming Protein, Perforin [Chemical/Ingredient], Cytolysin 
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the therapeutic use of transferred T cells… Expand
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Highly Cited
2007
Highly Cited
2007
Granzyme B is important for the ability of NK cells and CD8(+) T cells to kill their targets. However, we showed here that… Expand
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Highly Cited
2005
Highly Cited
2005
CD4+CD25+ regulatory T cells (Treg) are potent immunosuppressive cells that are pivotal in the regulation of peripheral tolerance… Expand
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Highly Cited
2004
Highly Cited
2004
Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill virally infected cells and tumor cells… Expand
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Highly Cited
2002
Highly Cited
2002
It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8… Expand
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Highly Cited
1999
Highly Cited
1999
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, rapidly fatal, autosomal recessive immune disorder characterized by… Expand
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Highly Cited
1994
Highly Cited
1994
Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T… Expand
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Highly Cited
1994
Highly Cited
1994
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To… Expand
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Highly Cited
1994
Highly Cited
1994
THE recent generation of perform knock-out mice1,2 has demonstrated a crucial role for the pore-forming perforin in cytolytic T… Expand
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Highly Cited
1991
Highly Cited
1991
Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction with target cells (TC). In this… Expand
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