PRF1 wt Allele

Known as: MGC65093, PFN1, Perforin 1 (Pore Forming Protein) wt Allele 
Human PRF1 wild-type allele is located in the vicinity of 10q22 and is approximately 5 kb in length. This allele, which encodes perforin-1 protein… (More)

Topic mentions per year

Topic mentions per year

2002-2017
012320022017

Papers overview

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2017
2017
BACKGROUND Animal researches reported that the dysfunction of profilin1 (PFN1) was involved in the physiological arterial… (More)
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2016
2016
Mutations in the profilin 1 (PFN1) gene cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease caused by the loss… (More)
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2016
2016
Profilin 1 (PFN1) is an actin monomer-binding protein essential for regulating cytoskeletal dynamics in all cell types. Recently… (More)
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2015
2015
Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of… (More)
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2013
2013
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown pathophysiological mechanisms. Profilin 1… (More)
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2013
2013
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To… (More)
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2012
2012
Profilins are prominent regulators of actin dynamics. While most mammalian cells express only one profilin, two isoforms, PFN1… (More)
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2008
2008
Perforin is involved in cell-mediated cytotoxicity and mutations of its gene (PRF1) cause familial hemophagocytic… (More)
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2004
2004
Profilin 1 (PFN1) is a regulator of the microfilament system and is involved in various signaling pathways. It interacts with… (More)
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2002
2002
Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So… (More)
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