Antitumor Response

An antitumor response involves destruction of cancer tumor cells primarily by activated T-cells induced to react to antigens recognized as foreign… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2017
05010019662017

Papers overview

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Review
2015
Review
2015
Chemotherapy and radiotherapy have been extensively used to eradicate cancer based on their direct cytocidal effects on rapidly… (More)
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Highly Cited
2007
Highly Cited
2007
Clinical studies with bortezomib have validated the proteasome as a therapeutic target for the treatment of multiple myeloma and… (More)
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Highly Cited
2006
Highly Cited
2006
Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function… (More)
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Highly Cited
2005
Highly Cited
2005
A major barrier to successful antitumor vaccination is tolerance of high-avidity T cells specific to tumor antigens. In keeping… (More)
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Highly Cited
2002
Highly Cited
2002
Development of tumor immunotherapies focuses on inducing autoimmune responses against tumor-associated self-antigens primarily… (More)
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Highly Cited
2001
Highly Cited
2001
Therapeutic efficacy of a tumor cell-based vaccine against experimental B16 melanoma requires the disruption of either of two… (More)
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Highly Cited
2000
Highly Cited
2000
Cyclooxygenase-2 (COX-2), the enzyme at the rate-limiting step of prostanoid production, has been found to be overexpressed in… (More)
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Highly Cited
1997
Highly Cited
1997
Although IL-12 possesses the most potent single-cytokine antitumor efficacy, the mechanism by which IL-12 exerts its antitumor… (More)
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Highly Cited
1993
Highly Cited
1993
IP-10 is a member of the -C-X-C-chemokine superfamily of proinflammatory cytokines whose secretion is induced by interferon gamma… (More)
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Highly Cited
1990
Highly Cited
1990
A poorly immunogenic murine colon cancer was used to investigate mechanisms of antitumor immunity. Injection of tumor cells… (More)
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