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Antitumor Response

An antitumor response involves destruction of cancer tumor cells primarily by activated T-cells induced to react to antigens recognized as foreign… 
National Institutes of Health

Related topics

Related topics

6 relations
AntigensHost-Tumor InteractionImmunityPRF1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response
The insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor tyrosine kinase that mediates cell survival… 
Highly Cited
2010
Highly Cited
2010
Superior Antitumor Response Induced by Large Stress Protein Chaperoned Protein Antigen Compared with Peptide Antigen
Our previous studies have demonstrated that the natural chaperone complexes of full-length tumor protein Ags (e.g., gp100) and… 
2005
2005
Oncolytic herpes simplex virus mutants are more efficacious than wild‐type adenovirus Type 5 for the treatment of high‐risk neuroblastomas in preclinical models
High‐risk neuroblastoma (Nb) is incurable using current treatment regimens in the majority of patients. Oncolytic virotherapy is… 
2004
2004
CD4-Directed Peptide Vaccination Augments an Antitumor Response, but Efficacy Is Limited by the Number of CD8+ T Cell Precursors1
Peptide vaccination is an immunotherapeutic strategy being pursued as a method of enhancing Ag-specific antitumor responses. To… 
Highly Cited
2002
Highly Cited
2002
Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.
Constitutive activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STAT) occurs at very high… 
2000
2000
The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status
The expression of costimulatory molecules such as CD70 or CD80 by gene-modified tumor cells has been shown to enhance the… 
Highly Cited
1998
Highly Cited
1998
Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.
CD70 (CD27 ligand (CD27L)), CD153 (CD30L), and CD154 (CD40L) are members of the tumor necrosis factor family of costimulatory… 
1997
1997
B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in lymph nodes.
Efficient T cell activation requires two synergistic but distinct signals derived from antigenic peptides presented by the MHC… 
Highly Cited
1996
Highly Cited
1996
Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.
The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for… 
Highly Cited
1985
Highly Cited
1985
Mullerian inhibiting substance reduction of colony growth of human gynecologic cancers in a stem cell assay.
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