The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status

@article{DouinEchinard2000TheEO,
  title={The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status},
  author={Victorine Douin-Echinard and St{\'e}phanie Bornes and Philippe Rochaix and A F Tilkin and Jean-Marie P{\'e}ron and Jacques E Bonnet and Gilles Favre and Bettina Couderc},
  journal={Cancer Gene Therapy},
  year={2000},
  volume={7},
  pages={1543-1556}
}
The expression of costimulatory molecules such as CD70 or CD80 by gene-modified tumor cells has been shown to enhance the antitumor immune response based mainly on T lymphocytes. However, most human tumors show defects of major histocompatibility complex (MHC) expression, preventing them from being recognized by MHC-restricted T cells. To investigate if… CONTINUE READING