PRF1 gene

Known as: P1, perforin 1 (preforming protein), PERFORIN 1 
This gene is involved in cytolysis.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC… (More)
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Highly Cited
2010
Highly Cited
2010
Interleukin(IL)-2 and inflammation regulate effector and memory cytolytic T-lymphocyte (CTL) generation during infection. We… (More)
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Highly Cited
2006
Highly Cited
2006
Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal-recessive disease that affects young children. It presents as a… (More)
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Highly Cited
2005
Highly Cited
2005
CD4+CD25+ regulatory T cells (Treg) are potent immunosuppressive cells that are pivotal in the regulation of peripheral tolerance… (More)
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Highly Cited
2004
Highly Cited
2004
Natural killer cells are important cytolytic cells in innate immunity. We have characterized human NK cells of spleen, lymph… (More)
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Highly Cited
2002
Highly Cited
2002
It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8… (More)
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Highly Cited
2000
Highly Cited
2000
The use of peptide-human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8… (More)
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Highly Cited
1999
Highly Cited
1999
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, rapidly fatal, autosomal recessive immune disorder characterized by… (More)
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Highly Cited
1997
Highly Cited
1997
Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or… (More)
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Highly Cited
1994
Highly Cited
1994
Mice lacking the perforin gene were generated by using targeted gene disruption in embryonal stem cells. When infected with… (More)
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