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PRF1 gene

Known as: P1, perforin 1 (preforming protein), PERFORIN 1 
This gene is involved in cytolysis.
National Institutes of Health

Related topics

Related topics

12 relations
Antitumor ResponseAntiviral ResponseApoptosisCell-Mediated Cytolysis

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PRF1 wt Allele

Papers overview

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Highly Cited
2006
Highly Cited
2006
Expansion and Diversification of Virus-Specific T Cells following Immunization of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals with a Recombinant Modified Vaccinia Virus Ankara…
ABSTRACT Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1… 
Highly Cited
2001
Highly Cited
2001
Antiviral Cd8+ T Cell Responses in Neonatal Mice
Polyoma virus is a potent oncogenic pathogen when inoculated into newborn mice of particular H-2k strains. Using Dk tetramers… 
Highly Cited
2000
Highly Cited
2000
MHC class I‐restricted killing of neurons by virus‐specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
Induction of MHC class I genes in neurons of the central nervous system requires signals by pro‐inflammatory cytokines, in… 
Highly Cited
1999
Highly Cited
1999
Homeostatic regulation of CD8+ T cells by perforin
To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by… 
Highly Cited
1999
Highly Cited
1999
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.
BACKGROUND Residual HIV-1-infected cells are poorly eliminated from lymphoid tissue (LT) reservoirs by effector cytotoxic T… 
Highly Cited
1998
Highly Cited
1998
Mechanisms of beta cell death in diabetes: a minor role for CD95.
Insulin-dependent diabetes mellitus is an autoimmune disease, under polygenic control, manifested only when >90% of the insulin… 
Highly Cited
1998
Highly Cited
1998
Molecular mechanisms of immune-mediated lysis of murine renal cancer: differential contributions of perforin-dependent versus Fas-mediated pathways in lysis by NK and T cells.
Mice bearing the experimental murine renal cancer Renca can be successfully treated with some forms of immunotherapy. In the… 
Highly Cited
1994
Highly Cited
1994
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
Lymphocyte-mediated cytotoxicity has been proposed to consist of the polarized secretion of granule-stored perforin leading to… 
Highly Cited
1993
Highly Cited
1993
In situ cDNA polymerase chain reaction. A novel technique for detecting mRNA expression.
We report a novel method for detecting intracellular messenger RNA by combining the techniques of in situ hybridization and… 
Highly Cited
1991
Highly Cited
1991
Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme…
Mouse gut intraepithelial lymphocytes (IEL), whether thymodependent (CD4+ or CD8 alpha/beta +; TCR-alpha/beta +) or… 
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