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Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
TLDR
It is shown that the commensal gut flora—in the absence of pathogenic agents—is essential in triggering immune processes, leading to a relapsing–remitting autoimmune disease driven by myelin-specific CD4+ T cells. Expand
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47.
TLDR
It is suggested that microRNA dysregulated in multiple sclerosis lesions reduce CD47 in brain resident cells, releasing macrophages from inhibitory control, thereby promoting phagocytosis of myelin and have broad implications for microRNA-regulated macrophage activation in inflammatory diseases. Expand
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
TLDR
Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, this work presents in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. Expand
Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
TLDR
Using anti-BDNF monoclonal antibody and polyclonal antiserum, BDNF immunoreactivity is demonstrable ininflammatory infiltrates in the brain of patients with acute disseminated encephalitis and multiple sclerosis, raising the possibility that in the nervous system, inflammatory infiltrates have a neuroprotective effect, which may limit the success of nonselective immunotherapies. Expand
Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis.
Homing behavior and function of autoimmune CD4+ T cells in vivo was analyzed before and during EAE, using MBP-specific T cells retrovirally engineered to express the gene of green fluorescentExpand
Cellular immune reactivity within the CNS
TLDR
Using autoaggressive rat T lymphocyte lines specific for defined protein components of peripheral or central myelin to study lymphocyte migration and antigen recognition within the nervous system suggests that the nervoussystem is constantly patrolled by low numbers of activated T cells. Expand
Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
We describe new T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92–106 in the context of I-As.Expand
B Lymphocytes Producing Demyelinating Autoantibodies: Development and Function in Gene-targeted Transgenic Mice
We studied the cellular basis of self tolerance of B cells specific for brain autoantigens using transgenic mice engineered to produce high titers of autoantibodies against the myelin oligodendrocyteExpand
T cells become licensed in the lung to enter the central nervous system
TLDR
It is detected that the lung constitutes a niche not only for activated T cells but also for resting myelin-reactive memory T cells, which could contribute to the activation of potentially autoaggressive T cells and their transition to a migratory mode as a prerequisite to entering their target tissues and inducing autoimmune disease. Expand
Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis
TLDR
Compared the Ig transcriptomes of B cells with the corresponding Ig proteomes in CSF samples from four subjects with multiple sclerosis, it is shown that CSF B cells indeed produce the oligoclonal Ig bands. Expand
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