PRF1 protein, human

Known as: Lymphocyte Pore-Forming Protein, perforin 1, human, Cytolysin 
Perforin-1 (555 aa, ~61 kDa) is encoded by the human PRF1 gene. This protein is involved in the mediation of cytolysis of infected cells.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2018
024619822018

Papers overview

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2017
2017
BACKGROUND Acute lower respiratory tract infection is the commonest disease affecting children under five worldwide. Respiratory… (More)
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2016
2016
Perforin-1 mutations result in a potentially fatal hemophagocytic lymphohistiocytosis (HLH) with heightened immune activation… (More)
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Review
2016
Review
2016
Immunology is the science of biological warfare between the defenses of our immune systems and offensive pathogenic microbes and… (More)
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2014
2014
BACKGROUND Perforin-1 (Prf1) is the predominant cytolytic protein secreted by natural killer (NK) cells. For a rapid immune… (More)
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2013
2013
Inherited defects of granule-dependent cytotoxicity led to the life-threatening immune disorder hemophagocytic… (More)
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2012
2012
BACKGROUND This study aimed to investigate the prevalence of mutations in the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK in… (More)
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2012
2012
Perforin-1 (PRF), a cytotoxic lymphocyte pore-forming protein, plays an important role in the action of cytotoxic T cells and… (More)
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Highly Cited
2008
Highly Cited
2008
To understand the mechanism regulating the effector function of memory CD8 T cells, we examined expression and chromatin state of… (More)
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Highly Cited
2006
Highly Cited
2006
Natural killer (NK) cells from patients with familial hemophagocytic lymphohistiocytosis because of PRF1 (FHL2, n = 5) or MUNC13… (More)
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2001
2001
Profilin (PRF) is a low-molecular-weight actin binding protein encoded by a diverse gene family in plants. Arabidopsis PRF1… (More)
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