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oblimersen

Known as: olbimersen, BCL2 Gene Anticode Oligodeoxynucleotide, 5'-tct ccc agc gtg cgc cat 
A phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Antineoplastic AgentsOligodeoxyribonucleotides, AntisenseThionucleotides
BCL2 protein, humanPositive Regulation of ApoptosisRNA BindingTranslational Repression

Narrower (3)

G-3139 oligonucleotideGenasenseoblimersen sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
The long march of antisense
Antisense therapy has generated waves of enthusiasm and disappointment. With a new drug about to be submitted for approval, is it… 
Review
2010
Review
2010
Therapy of chronic lymphocytic leukaemia.
2009
2009
Phase I study of apoptosis gene modulation with oblimersen within preoperative chemotherapy in patients with primary breast cancer.
Expression of the Bcl-2 protein confers resistance to chemotherapy-mediated apoptotic signals in patients with breast cancer. We… 
Highly Cited
2007
Highly Cited
2007
A phase III randomized trial of intensive induction and consolidation chemotherapy ± oblimersen, a pro-apoptotic Bcl-2 antisense oligonucleotide in untreated acute myeloid leukemia patients >60 years…
7012 Background: Overexpression of Bcl-2, an inhibitor of apoptosis, may render AML cells resistant to chemotherapy and has been… 
Review
2007
Review
2007
Targeting the Cell Death-Survival Equation
This issue of CCR Focus comprises four representative articles that closely fit the research interests of Stanley J. Korsmeyer… 
2006
2006
The Combination of the Proteasome Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen Sensitizes Human B-Cell Lymphomas to Cyclophosphamide
Purpose: To determine whether the combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen… 
Review
2005
Review
2005
Bcl-2 antisense therapy in B-cell malignancies.
2003
2003
G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.
G3139 is an 18-mer phosphorothioate oligodeoxyribonucleotide, which is targeted to the initiation codon region of the bcl-2mRNA… 
1996
1996
The relative contributions of dispersion and diffusion to band spreading (resolution) in gel electrophoresis
DNA of approximately 2 kbp in length was previously found not to diffuse significantly in 1–1.5% agarose gels in the absence of… 
1996
1996
Glucose tolerance and insulin secretion after adrenalectomy in mice made obese with gold thioglucose.
The effect of adrenalectomy (ADX) on glucose tolerance and insulin secretion was examined in conscious mice made obese by a… 
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