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Genasense

 
National Institutes of Health

Papers overview

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2009
2009
OBJECTIVES Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy of the skin. Preclinical studies have… Expand
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2006
2006
PURPOSE To assess the feasibility and antitumor activity of oblimersen sodium, an antisense oligonucleotide directed to the Bcl-2… Expand
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2004
2004
New strategies have evolved in the treatment of patients with non-Hodgkin's lymphoma (NHL). Anti-sense oligonucleotides (ASO) and… Expand
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2004
2004
PURPOSE To assess the feasibility of administering oblimersen sodium, a phosphorothioate antisense oligonucleotide directed to… Expand
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Highly Cited
2003
Highly Cited
2003
Overexpression of Bcl-2 is a potential mechanism for chemoresistance in acute leukemia and has been associated with unfavorable… Expand
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2003
2003
Bcl-2 is up-regulated by EBV in immortalized lymphoblastoid B cells and is expressed in the majority of EBV-associated… Expand
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Review
2002
Review
2002
The components of the apoptotic program are targets for anticancer therapy. Bcl-2 protein inhibits apoptosis and confers… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE Bcl-2 is a negative prognostic indicator in prostate cancer, implicated in the development of androgen independence and… Expand
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Review
2001
Review
2001
Genasense (formerly known as G-3139), an antisense oligonucleotide specific for Bcl-2, is under development by Genta as an iv… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Chemoresistance of malignant melanoma has been linked to expression of the proto-oncogene BCL2. Antisense… Expand
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