Genasense
National Institutes of Health
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SummaryBackground: Overexpression of Bcl-2 is associated with worse prognosis for a number of cancer types. The present study was…
Advanced hepatocellular (HCC) is refractory to most standard forms of chemotherapy, however responses to doxorubicin are seen [1…
Bcl-2 is an oncoprotein that plays a critical role in inhibiting apoptotic cell death in the mitochondria-dependent pathway in…
PURPOSE
To assess the feasibility and antitumor activity of oblimersen sodium, an antisense oligonucleotide directed to the Bcl-2…
Bcl‐2 is anti‐apoptotic and overexpression is associated with prostate tumor aggressiveness. We hypothesized that Bcl‐2 has a…
7505 Background: Chemotherapy resistance of MM has been linked to Bcl-2, an anti-apoptotic protein over-expressed in > 80% of pts…
The results of treatment for metastatic melanoma remain disappointing. Single-agent chemotherapy produces response rates ranging…
Bcl-2 is an anti-apoptotic protein that has been closely linked to chemotherapy resistance and inferior survival in patients (pts…
Bcl-2 is up-regulated by EBV in immortalized lymphoblastoid B cells and is expressed in the majority of EBV-associated…
PURPOSE
The near-universal emergence of imatinib resistance in patients with acute forms of Philadelphia chromosome-positive…