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G-3139 oligonucleotide

Known as: G3139 BCL-2 Antisense Oligodeoxynucleotide, bcl-2 antisense oligonucleotide (G3139), G3139 BCL-2 Antisense 
National Institutes of Health

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Broader (1)

oblimersen
oblimersen sodium

Papers overview

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Review
2007
Review
2007
Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy
Bcl-2 is an oncoprotein that plays a critical role in inhibiting apoptotic cell death in the mitochondria-dependent pathway in… 
Highly Cited
2001
Highly Cited
2001
Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer.
Highly Cited
2001
Highly Cited
2001
Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model
Abstract. We used Bcl-2 antisense oligonucleotides (G3139) to chemosensitize human gastric cancer by downregulation of Bcl-2… 
Highly Cited
2000
Highly Cited
2000
Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.
Cancers overexpressing Bcl-2 protein, which prevents programmed cell death (apoptosis), are less sensitive to stresses that… 
Highly Cited
2000
Highly Cited
2000
Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin.
Bcl-2 is a key apoptosis-regulating protein that has been implicated in mechanisms of chemoresistance for a variety of… 
Highly Cited
2000
Highly Cited
2000
Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression
We have investigated the effects of transient Bcl-2 down-regulation induced by the Bcl-2 antisense oligodeoxynucleotide (ODN… 
Highly Cited
1997
Highly Cited
1997
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection
Isolated outer membranes of Borrelia burgdorferi 297 were utilized to obtain partial amino acid sequence information for a low… 
Highly Cited
1994
Highly Cited
1994
The detection of tomato spotted wilt virus using the polymerase chain reaction.
Highly Cited
1993
Highly Cited
1993
Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: evidence for expression of ETB…
Our aim was to characterize and determine the function of endothelin (ET) receptor subtypes in human vascular tissue. Reverse… 
Highly Cited
1989
Highly Cited
1989
Detection of specific DNA sequences by fluorescence amplification: a color complementation assay.
We have developed a color complementation assay that allows rapid screening of specific genomic DNA sequences. It is based on the… 
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