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Dopamine and glutamate receptors are densely expressed in the nucleus accumbens (NAc). Active interactions between these… Expand Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations… Expand RationaleDopamine is strongly implicated in the ability to shift behavior in response to changing stimulus-reward contingencies… Expand Dopamine D3 receptor partial agonism has been suggested as a potential therapeutic intervention in cocaine addiction. RGH-237 [N… Expand The conditioning of cocaine's pharmacological actions with environmental stimuli is thought to be a critical factor in long… Expand The benzofurane (+)-S 14297, the benzamide nafadotride, the aminoindane U 99194 and the arylpiperazine GR 103,691 have been… Expand In rats with unilateral lesions of the nigrostriatal dopamine pathway with 6-hydroxydopamine, the motor stimulating effects of… Expand Nafadotride has been proposed as a selective antagonist for the D3 dopamine receptor. This drug has been shown to exhibit… Expand The three dopamine agonists with highest reported D3 receptor selectivity in vitro, pramipexole, quinelorane and PD128,907… Expand Nafadotride (N[(n-butyl-2-pyrrolidinyl)methyl]-1-methoxy-4-cyano naphtalene-2-carboxamide) is a novel compound, which inhibits… Expand