Psychomotor-activating effects mediated by dopamine D2 and D3 receptors in the nucleus accumbens

@article{Canales2000PsychomotoractivatingEM,
  title={Psychomotor-activating effects mediated by dopamine D2 and D3 receptors in the nucleus accumbens},
  author={Juan J Canales and Susan D. Iversen},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={67},
  pages={161-168}
}
  • J. Canales, S. Iversen
  • Published 1 September 2000
  • Biology, Psychology
  • Pharmacology Biochemistry and Behavior
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Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
TLDR
The findings indicate that impulsivity and hyperactivity are separately regulated by core and shell sub-regions of the NAcb and that HI rats show an enhanced response to D2/3 receptor activation in these regions.
Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways
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A panel of structurally related substituted 4‐phenylpiperazines with nanomolar affinity and selectivity at D3 dopamine receptors has been synthesized and it is shown that the heterocyclic amide moiety appears to be the pivotal structural element determining the intrinsic efficacy of these D3 receptor selective compounds.
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