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The behavioural effects of pramipexole, a novel dopamine receptor agonist.
Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats
Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations
The results indicate that sertraline and citalopram given repeatedly decrease the responsiveness of 5-HT1A (presynaptic) and5-HT2 receptors but increase the responsivenessof 5- HT1B receptors to respective agonists.
Hypotheses concerning the mechanism of action of antidepressant drugs.
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats
Activity of 72-kDa and 92-kDa matrix metalloproteinases in placental tissues of cows with and without retained fetal membranes.
Antidepressant effects of pramipexole, a novel dopamine receptor agonist
Results indicate that, in the tests used, pramipexole evokes effects similar to those of typical antidepressants and, at the same time, enhances their activity (the forced swimming test in rats); therefore it may be regarded as a potential antidepressant drug.
Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.
Conversion into a radioresistant tumor phenotype when implanted in SCID(asmase-/-) hosts provides compelling evidence that cell membrane ASMase-mediated microvascular dysfunction, rather than DNA damage-mediated endothelial clonogenic lethality, plays a mandatory role in the complex pathophysiologic mechanism of tumor cure by SDRT.
Locomotor hyperactivity induced by MK-801 in rats.
- J. Maj, Z. Rogóż, G. Skuza
- Biology, PsychologyPolish journal of pharmacology and pharmacy
- 1 November 1991
The results indicate that the dopamine system is mainly involved in the locomotor hyperactivity induced by MK-801, which was antagonized by haloperidol and, to a lesser degree, by SCH 23390 and sulpiride.
Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity
The obtained results indicate that CGP 37849 administered alone or in combination with L-DOPA or clonidine may be a potential antiparkinsonian drug.