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The role of dopamine in locomotor activity and learning
  • R. Beninger
  • Medicine, Psychology
  • Brain Research Reviews
  • 1 October 1983
It is suggested that the biological substrate of DA-mediated incentive learning is a heterosynaptic facilitation of muscarinic cholinergic synapses, which has important clinical implications since it has been suggested that DA hyperfunctioning underlies the development of schizophrenia. Expand
Dopamine D1-like Receptors and Reward-related Incentive Learning
The molecular mechanism underlying DA-mediated incentive learning may involve DA release in association with reward, stimulation of D1-like receptors, activation of the cAMP/PKA cascade and additional intracellular events leading to modification of cortico-striatal glutamatergic synapses activated by stimuli encountered in close temporal contiguity with reward. Expand
The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by Δ9-tetrahydrocannabinol or anandamide
This is the first report that the memory impairment produced by anandamide can be attenuated by a cannabinoid antagonist; results suggest that an andamide-induced memory disruption is mediated by CB1 receptors. Expand
Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats.
It is suggested that ERK and p38, but not JNK, MAPKs may be necessary for the establishment of NAc amphetamine-produced CPP and may also mediate other forms of reward-related learning dependent on NAc. Expand
Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation
It is suggested that schizophrenic patients treated with typical antipsychotic medications will have impaired probabilistic classification learning (PCL) and that similar patients treating with atypical antipsychotics will have impairing learning of the gambling task. Expand
Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in rats.
In ultra-low doses, naltrexone paradoxically enhances morphine analgesia and inhibits or reverses tolerance through a spinal action and may have implications for chronic treatment with agonist-antagonist combinations. Expand
Caffeine-induced place and taste conditioning: Production of dose-dependent preference and aversion
Caffeine appeared to produce a dose-dependent biphasic effect; a lower dose was rewarding, whereas higher doses produced aversions to environmental stimuli associated with the drug. Expand
Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.
The results fail to implicate the endogenous cannabinoid anandamide in reward-related learning or aversion and the half-life of an andamide was increased by pretreatment with the protease inhibitor phenylmethylsulfonyl fluoride. Expand
Effects of Parkinson Disease on Two Putative Nondeclarative Learning Tasks: Probabilistic Classification and Gambling
The PCL and IGT tasks appear to rely on different parts of the frontostriatal circuitry in patients with early PD, implying ventromedial prefrontal cortical dysfunction early in the disease. Expand
The role of signaling molecules in reward-related incentive learning
Results support a model of DA-Glu synaptic interactions that form the basis of incentive learning and suggest that PKA is more important for acquisition than expression of incentiveLearning. Expand