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Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex
TLDR
The data indicate that the PFC is a brain site at which the 5-HT2CR exerts an inhibitory control over the hyperactive and discriminative stimulus effects of cocaine known to be dependent upon activation of the DA mesoaccumbens circuit.
Differential Regulation of the Mesoaccumbens Circuit by Serotonin 5-Hydroxytryptamine (5-HT)2A and 5-HT2CReceptors
TLDR
These findings are the first to demonstrate that the behavioral effects of cocaine are generated in part by activation of 5-HT2ARs in the VTA and byactivation of 4-trifluoromethylphenylsulfon-amido)phenyl-5-oxopentyl in the NAc shell.
Involvement of cannabinoid CB1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine.
TLDR
It was found that endocannabinoids were not involved in maintenance of cocaine reinforcement and its subjective effects since pharmacological blockade of cannabinoid CB(1) receptors altered neither self-administration nor discriminative stimulus effects of cocaine.
Oxidative Stress in Neurodegenerative Diseases
TLDR
The effects of the drug-induced modulation of oxidative balance, and pharmacotherapeutic strategies for OS reduction are analyzed, and they are explored.
Effects of GABAB receptor ligands in animal tests of depression and anxiety.
TLDR
The results indicate that differential manipulation of GABA(B) receptors can modify behaviors relevant to depression and anxiety.
Contribution of Serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2 Receptor Subtypes to the Hyperlocomotor Effects of Cocaine: Acute and Chronic Pharmacological Analyses
TLDR
The present study implies that 5-HT2AR and 5- HT2CR exert oppositional influence upon hyperactivity evoked by acute administration of cocaine; this balance is altered following repeated cocaine administration.
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