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motexafin gadolinium

Known as: Gd (III) Texaphryin, Gadolinium Texaphyrin, Gd(III) texaphyrin 
A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (4)

Antineoplastic AgentsContrast MediaMetalloporphyrinsPhotosensitizing Agents
DNA Breaks, Double-StrandedFree Radical FormationPositive Regulation of Apoptosischemosensitization/potentiation

Narrower (1)

Xcytrin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Motexafin gadolinium: a novel radiosensitizer for brain tumors
For a variety of reasons, the management of brain tumors, both primary and metastatic, remains a considerable challenge. As most… 
Review
2007
Review
2007
Motexafin gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer
Despite recent advances in technology, targeting, and chemotherapy, brain metastasis from non-small cell lung cancer (NSCLC… 
Highly Cited
2006
Highly Cited
2006
Motexafin-Gadolinium Taken Up In vitro by at Least 90% of Glioblastoma Cell Nuclei
Purpose: We present preclinical data showing the in vitro intranuclear uptake of motexafin gadolinium by glioblastoma multiforme… 
2005
2005
Population Pharmacokinetics of Motexafin Gadolinium in Adults With Brain Metastases or Glioblastoma Multiforme
The purpose of this study was to determine clinical variables affecting motexafin gadolinium (MGd) pharmacokinetics. Motexafin… 
Review
2004
Review
2004
Motexafin gadolinium: a clinical review of a novel radioenhancer for brain tumors
Despite recent advances in both technology and molecular targeting, little progress has been made in the management of most… 
2002
2002
Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.
Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a… 
2002
2002
Preliminary studies of the effects of gadolinium texaphyrin on the growth and radiosensitivity of EMT6 cells in vitro.
2000
2000
Re-evaluating gadolinium(III) texaphyrin as a radiosensitizing agent.
Gadolinium(III) texaphyrin (Gd-tex) was recently proposed as a radiosensitizing agent that combines preferential tumor uptake… 
2000
2000
Reversible Renal Toxicity Resulting From High Single Doses of the New Radiosensitizer Gadolinium Texaphyrin
Gadolinium (III) texaphyrin (Gd-Tex) (NSC 695238) is a potential radiation sensitizer that selectively localizes in tumors and is… 
1996
1996
New texaphyrin-type expanded porphyrins
Abstract 
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