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motexafin gadolinium

Known as: Gd (III) Texaphryin, Gadolinium Texaphyrin, Gd(III) texaphyrin 
A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (4)

Antineoplastic AgentsContrast MediaMetalloporphyrinsPhotosensitizing Agents
DNA Breaks, Double-StrandedFree Radical FormationPositive Regulation of Apoptosischemosensitization/potentiation
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Narrower (1)

Xcytrin

Papers overview

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Highly Cited
2008
Highly Cited
2008
Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study.
The purpose of this study was to determine the dose-limiting toxicities, maximum tolerated dose, pharmacokinetics, and intratumor… Expand
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Review
2006
Review
2006
Motexafin gadolinium: a novel redox active drug for cancer therapy.
Motexafin gadolinium (MGd, Xcytrin) is an aromatic macrocycle that has a strong affinity for electrons, i.e., it is easily… Expand
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Highly Cited
2006
Highly Cited
2006
Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase*
Motexafin gadolinium (MGd) is a chemotherapeutic drug that selectively targets tumor cells and mediates redox reactions… Expand
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Highly Cited
2003
Highly Cited
2003
Phase I Drug and Light Dose-Escalation Trial of Motexafin Lutetium and Far Red Light Activation (Phototherapy) in Subjects With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention…
Background—Motexafin lutetium (MLu; Antrin) is a photosensitizer that is taken up by atherosclerotic plaque and concentrated… Expand
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Highly Cited
2001
Highly Cited
2001
Effects of Motexafin gadolinium on tumor metabolism and radiation sensitivity.
PURPOSE Experiments were undertaken to determine if metabolic changes induced by Motexafin gadolinium (Gd-Tex(+2), XCYTRIN… Expand
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Highly Cited
2001
Highly Cited
2001
Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species.
PURPOSE To examine the mechanism of radiation enhancement by motexafin gadolinium (Gd-Tex) in vitro. METHODS AND MATERIALS… Expand
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Highly Cited
2001
Highly Cited
2001
Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases.
PURPOSE Motexafin gadolinium is a magnetic resonance imaging (MRI)--detectable redox active drug that localizes selectively in… Expand
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Highly Cited
1999
Highly Cited
1999
In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer.
PURPOSE Gadolinium texaphyrin (Gd-Tex, PCI-0120) is an expanded porphyrin that has demonstrated radiation enhancement. In this… Expand
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Highly Cited
1996
Highly Cited
1996
Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.
Gadolinium(III) texaphyrin (Gd-tex2+) is representative of a new class of radiation sensitizers detectable by magnetic resonance… Expand
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Highly Cited
1996
Highly Cited
1996
Lutetium texaphyrin (PCI-0123): a near-infrared, water-soluble photosensitizer.
Lutetium texaphyrin, PCI-0123, is a pure, water-soluble photosensitizer with a large broad absorption band centered at 732 nm… Expand
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