motexafin gadolinium

Known as: Gd (III) Texaphryin, Gadolinium Texaphyrin, Gd(III) texaphyrin 
A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially… (More)
National Institutes of Health

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Broader (4)

Antineoplastic AgentsContrast MediaMetalloporphyrinsPhotosensitizing Agents
DNA Breaks, Double-StrandedFree Radical FormationPositive Regulation of Apoptosischemosensitization/potentiation
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Narrower (1)

Xcytrin

Papers overview

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2009
2009
Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).
Motexafin gadolinium (MGd) is an expanded porphyrin anticancer agent which selectively targets tumor cells and works as a… (More)
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Review
2007
Review
2007
Motexafin gadolinium in the treatment of brain metastases.
Motexafin gadolinium (MGd) is a novel, MRI-detectable, anticancer agent that enhances the cytotoxic potential of radiation… (More)
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Highly Cited
2006
Highly Cited
2006
Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.
Motexafin gadolinium (MGd) is a chemotherapeutic drug that selectively targets tumor cells and mediates redox reactions… (More)
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2005
2005
Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines.
To gain a better understanding of the mechanism of action of the metal cation-containing chemotherapeutic drug motexafin… (More)
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2005
2005
Motexafin gadolinium induces mitochondriallymediated caspase-dependent apoptosis
Motexafin gadolinium (MGd, Xcytrin®) is a tumor-localizing redox mediator that catalyzes the oxidation of intracellular reducing… (More)
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2004
2004
Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells.
Motexafin gadolinium (MGd), an expanded porphyrin, is a tumor-selective redox-mediator that reacts with many intracellular… (More)
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2002
2002
Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.
Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a… (More)
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2001
2001
Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases.
PURPOSE Motexafin gadolinium is a magnetic resonance imaging (MRI)--detectable redox active drug that localizes selectively in… (More)
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2001
2001
Effects of Motexafin gadolinium on tumor metabolism and radiation sensitivity.
PURPOSE Experiments were undertaken to determine if metabolic changes induced by Motexafin gadolinium (Gd-Tex(+2), XCYTRIN… (More)
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2001
2001
Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species.
PURPOSE To examine the mechanism of radiation enhancement by motexafin gadolinium (Gd-Tex) in vitro. METHODS AND MATERIALS… (More)
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