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DNA Breaks, Double-Stranded

Known as: DNA Breaks, Double Stranded, Break, Double-Stranded DNA, Break, Double-Strand DNA 
A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in… Expand
National Institutes of Health

Related topics

Related topics

8 relations
5-chloroquinoxaline-2-sulfanilamideChromosome StructuresDNA RepairDouble Strand Break Repair
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene… Expand
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Highly Cited
2012
Highly Cited
2012
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated… Expand
Review
2010
Review
2010
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
  • M. Lieber
  • Annual review of biochemistry
  • 2010
    • Corpus ID: 8437287
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous… Expand
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Highly Cited
2008
Highly Cited
2008
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… Expand
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Review
2008
Review
2008
Gamma-H2AX - a novel biomarker for DNA double-strand breaks.
When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks (DSBs), it is always followed by the… Expand
Highly Cited
2006
Highly Cited
2006
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
We show that DNA double-strand breaks (DSBs) induce complex subcompartmentalization of genome surveillance regulators. Chromatin… Expand
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Highly Cited
2004
Highly Cited
2004
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
The hereditary disorder ataxia telangiectasia (A-T) is associated with striking cellular radiosensitivity that cannot be… Expand
Review
2001
Review
2001
DNA double-strand breaks: signaling, repair and the cancer connection
To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms to monitor genome integrity. Cells… Expand
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Highly Cited
2001
Highly Cited
2001
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments… Expand
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Highly Cited
1995
Highly Cited
1995
Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure
An improved lithium acetate (LiAc)/single‐stranded DNA (SS‐DNA)/polyethylene glycol (PEG) protocol which yields >1 × 106… Expand
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