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DNA Breaks, Double-Stranded

Known as: DNA Breaks, Double Stranded, Break, Double-Stranded DNA, Break, Double-Strand DNA 
A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene… Expand
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Highly Cited
2012
Highly Cited
2012
Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated… Expand
Review
2010
Review
2010
  • M. Lieber
  • Annual review of biochemistry
  • 2010
  • Corpus ID: 8437287
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous… Expand
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Highly Cited
2008
Highly Cited
2008
DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… Expand
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Review
2008
Review
2008
When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks (DSBs), it is always followed by the… Expand
Highly Cited
2006
Highly Cited
2006
We show that DNA double-strand breaks (DSBs) induce complex subcompartmentalization of genome surveillance regulators. Chromatin… Expand
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Highly Cited
2004
Highly Cited
2004
The hereditary disorder ataxia telangiectasia (A-T) is associated with striking cellular radiosensitivity that cannot be… Expand
Review
2001
Review
2001
To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms to monitor genome integrity. Cells… Expand
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Highly Cited
2001
Highly Cited
2001
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments… Expand
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Highly Cited
1995
Highly Cited
1995
An improved lithium acetate (LiAc)/single‐stranded DNA (SS‐DNA)/polyethylene glycol (PEG) protocol which yields >1 × 106… Expand