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DNA Breaks, Double-Stranded

Known as: DNA Breaks, Double Stranded, Break, Double-Stranded DNA, Break, Double-Strand DNA 
A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in… 
National Institutes of Health

Related topics

Related topics

8 relations
5-chloroquinoxaline-2-sulfanilamideChromosome StructuresDNA RepairDouble Strand Break Repair

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.
Highly Cited
2006
Highly Cited
2006
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at… 
Highly Cited
2005
Highly Cited
2005
Absorption, Metabolization, and Antiplatelet Effects of 300-, 600-, and 900-mg Loading Doses of Clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose…
Background— For patients undergoing percutaneous coronary intervention, the administration of a clopidogrel loading dose ranging… 
Highly Cited
2003
Highly Cited
2003
Srs2 and Sgs1–Top3 Suppress Crossovers during Double-Strand Break Repair in Yeast
Highly Cited
2000
Highly Cited
2000
DNA Length Dependence of the Single-Strand Annealing Pathway and the Role of Saccharomyces cerevisiae RAD59 in Double-Strand Break Repair
ABSTRACT A DNA double-strand break (DSB) created by the HO endonuclease inSaccharomyces cerevisiae will stimulate recombination… 
Highly Cited
2000
Highly Cited
2000
Frequent chromosomal translocations induced by DNA double-strand breaks
The faithful repair of DNA damage such as chromosomal double-strand breaks (DSBs) is crucial for genomic integrity. Aberrant… 
Review
1998
Review
1998
Molecular mechanisms of DNA double strand break repair.
Highly Cited
1998
Highly Cited
1998
In situ visualization of DNA double-strand break repair in human fibroblasts.
A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand… 
Highly Cited
1996
Highly Cited
1996
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.
Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends… 
Highly Cited
1995
Highly Cited
1995
A controlled double blind study of azathioprine in the management of Crohn's disease.
While immunosuppressive agents are used widely in the management of Crohn's disease, their efficacy has not been well established… 
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