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DNA Breaks, Double-Stranded

Known as: DNA Breaks, Double Stranded, Break, Double-Stranded DNA, Break, Double-Strand DNA 
A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in… (More)

Topic mentions per year

Topic mentions per year

1992-2018
051019922018

Related topics

Related topics

8 relations
5-chloroquinoxaline-2-sulfanilamideChromosome StructuresDNA RepairDouble Strand Break Repair
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
DNA Breaks, Double-Stranded
DNA Repair
ametantrone
Double Strand Break Repair
Chromosome Structures
5-chloroquinoxaline-2-sulfanilamide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin.
Repetitive DNA is packaged into heterochromatin to maintain its integrity. We use CRISPR/Cas9 to induce DSBs in different… (More)
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2015
2015
Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5'-to-3' resection of Double-Strand DNA Breaks (DSBs… (More)
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2012
2012
Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.
A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic instability and profound genome… (More)
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2012
2012
Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and… (More)
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2011
2011
Targeting the DNA Double Strand Break Repair Machinery in Prostate Cancer
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease… (More)
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2010
2010
Ionizing Radiation, DNA Double Strand Break and Mutation
Ionizing radiation has been proved a major stress that can induce carcinogenesis. Nuclear DNA is the main target of ionizing… (More)
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2010
2010
The Caenorhabditis elegans Werner Syndrome Protein Functions Upstream of ATR and ATM in Response to DNA Replication Inhibition and Double-Strand DNA Breaks
WRN-1 is the Caenorhabditis elegans homolog of the human Werner syndrome protein, a RecQ helicase, mutations of which are… (More)
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2009
2009
Recruitment of Rad51 and Rad52 to Short Telomeres Triggers a Mec1-Mediated Hypersensitivity to Double-Stranded DNA Breaks in Senescent Budding Yeast
Telomere maintenance is required for chromosome stability, and telomeres are typically replicated by the action of telomerase. In… (More)
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2008
2008
Positive Regulation of DNA Double Strand Break Repair Activity during Differentiation of Long Life Span Cells: The Example of Adipogenesis
Little information is available on the ability of terminally differentiated cells to efficiently repair DNA double strand breaks… (More)
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2000
2000
Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks
Immature CD4(+)CD8(+) thymocytes rearrange their T cell receptor (TCR)-alpha gene locus to generate clonotypic alpha/beta TCR… (More)
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