DNA Breaks, Double-Stranded
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Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene… Expand Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated… Expand Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous… Expand DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single… Expand When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks (DSBs), it is always followed by the… Expand We show that DNA double-strand breaks (DSBs) induce complex subcompartmentalization of genome surveillance regulators. Chromatin… Expand The hereditary disorder ataxia telangiectasia (A-T) is associated with striking cellular radiosensitivity that cannot be… Expand To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms to monitor genome integrity. Cells… Expand RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments… Expand An improved lithium acetate (LiAc)/single‐stranded DNA (SS‐DNA)/polyethylene glycol (PEG) protocol which yields >1 × 106… Expand