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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.
Ras proteins participate as a molecular switch in the early steps of the signal transduction pathway that is associated with cell growth and differentiation. When the protein is in its GTP complexedExpand
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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
Mutations caused by oxidative DNA damage may contribute to human disease. A major product of that damage is 8-hydroxyguanine (oh8Gua). Because of differences in experimental design, the base pairingExpand
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Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair.
8-Hydroxydeoxyguanosine (8-OH-dG) was detected in DNA isolated from HeLa cells after the cells in tissue culture had been irradiated with X-rays and from the liver of mice after the whole animals hadExpand
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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer (pH 6.8) at 37 degrees C. Addition of hydrogen peroxide (H2O2)Expand
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Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.
Proton NMR analyses have been made to elucidate the conformational characteristics of modified nucleotides as found in the first position of the anticodon of tRNA [derivatives ofExpand
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Modified Nucleosides and Codon Recognition
This chapter focuses on the mechanisms by which the post-transcriptional modifications regulate the codon recognition of tRNAs, primarily from the viewpoint of conformational characteristics ofExpand
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Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
It has been shown previously that deoxyguanosine residues in DNA are hydroxylated at the C-8 position both in vitro and in vivo to produce 8-hydroxydeoxyguanosine (8-OH-dG) by various agents thatExpand
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Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification
An Escherichia coli isoleucine transfer RNA specific for the codon AUA (tRNA2Ile or tRNAminorIle (ref. 1) has a novel modified nucleo-side, lysidine (L; ref. 2) (Fig. la) in the first position of theExpand
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8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
Substrate specificities of FPG protein (also known as formamidopyrimidine DNA glycosylase) and 8-hydroxyguanine endonuclease were compared by using defined duplex oligodeoxynucleotides containingExpand
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Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
The backbone 1H, 13C, and 15N resonances of the c-Ha-Ras protein [a truncated version consisting of residues 1-171, Ras(1-171)] bound with GMPPNP (a slowly hydrolyzable analogue of GTP) were assignedExpand
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