S. Nishimura

Publications429
h-index73
Citations22,364
Highly Influential Citations400
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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.
TLDR
A comparison of eight three-dimensional structures of ras proteins in four different crystal lattices reveals that the "on" and "off" states of the switch are distinguished by conformational differences that span a length of more than 40 A, and are induced by the gamma-phosphate.
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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
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Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair.
TLDR
The results indicate that 8-OH-dG is formed in vivo in cellular DNA on treatment with various oxygen radical-producing agents and that it is repairable and that its content is increase in Salmonella typhimurium cells with hydrogen peroxide.
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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
TLDR
The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer in high yield with remarkably enhanced addition of hydrogen peroxide (H2O2).
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Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
TLDR
The syn-thetic oligodeoxynucleotides, with or without an 8-OH-dG residue in a specified position, were chemically synthesized and used as templates for DNA synthesis under the conditions of the dideoxy chain termination sequencing method.
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Modified Nucleosides and Codon Recognition
This chapter focuses on the mechanisms by which the post-transcriptional modifications regulate the codon recognition of tRNAs, primarily from the viewpoint of conformational characteristics of…
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8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
TLDR
8-oxodG DNA is the primary physiological substrate for a constituent glycosylase found in bacteria and mammalian cells, and it is proposed that the existence of a bacterial gene coding for FPG protein is proposed.
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Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.
TLDR
The biological significance of modifications of uridine to xm5s2U/xo5U is in the regulation of the conformational rigidity/flexibility in the first position of the anticodon so as to guarantee the correct and efficient translation of codons in protein biosynthesis.
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Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification
TLDR
Both the codon and amino-acid specificity of this tRNA are converted by a single post-transcriptional modification of the first position of the anticodon during tRNA maturation.
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Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
TLDR
It was shown that the Ras(1-171) protein bound with GTP or GTPgammaS exhibits the same type of broadening, and it is a characteristic feature of the GTP-bound form of Ras that the L1, L2, and L4 loop regions, but not other regions, are in a rather slow interconversion between two or more stable conformers.
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