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5-chloroquinoxaline-2-sulfanilamide

Known as: Chloroquinoxaline Sulfonamide, Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-, Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)- 
A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline… 
National Institutes of Health

Related topics

Related topics

9 relations
DNA Breaks, Double-StrandedDNA Repair InhibitionDNA topoisomerase II alphaNCIt Antineoplastic Agent Terminology

Broader (2)

QuinoxalinesSulfanilamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria.
In the previous paper [Gligorijevic, B., et al. (2006) Biochemistry 45, pp 12400-12410], we reported on a customized Nipkow… 
Highly Cited
2005
Highly Cited
2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties…
Highly Cited
2004
Highly Cited
2004
Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.
Review
2002
Review
2002
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium…
Chloroquine resistance (CQR) in Plasmodium falciparum is associated with multiple mutations in the digestive vacuole membrane… 
Highly Cited
1998
Highly Cited
1998
Laryngeal adduction in resonant voice.
Highly Cited
1998
Highly Cited
1998
Role for the plasmodium falciparum digestive vacuole in chloroquine resistance.
Highly Cited
1998
Highly Cited
1998
Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum
Here we describe the identification and characterization of a physiological marker that is associated with the chloroquine… 
Highly Cited
1997
Highly Cited
1997
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4… 
Highly Cited
1990
Highly Cited
1990
Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
THE lethal form of human malaria caused by Plasmodium falciparum is virtually uncontrollable in many areas because of the… 
Highly Cited
1990
Highly Cited
1990
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
CHLOROQUINE is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering… 
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