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DNA topoisomerase II alpha

Known as: DNA Topoisomerase II, Alpha Isozyme, EC 5.99.1.3, Topo II Alpha 
DNA topoisomerase 2-alpha (1531 aa, ~174 kDa) is encoded by the human TOP2A gene. This protein is involved in the modulation of DNA topology.
National Institutes of Health

Related topics

Related topics

17 relations
5-chloroquinoxaline-2-sulfanilamideATPase DomainCell NucleusChromosome Condensation

Broader (3)

Antigens, NeoplasmDNA-Binding ProteinsTopoisomerase II

Narrower (1)

TOP2A protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway.
Highly Cited
2014
Highly Cited
2014
A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high‐grade serous carcinoma development
Recent evidence suggests that ovarian high‐grade serous carcinoma (HGSC) originates from the epithelium of the fallopian tube… 
Highly Cited
2013
Highly Cited
2013
Anthracyclines and heart failure.
Doxorubicin and other anthracyclines are used to treat cancer, yet they elevate the risk of heart failure. A recent study… 
Highly Cited
2011
Highly Cited
2011
Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.
PURPOSE Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene… 
Highly Cited
2004
Highly Cited
2004
Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples
Recent clinical trials have suggested that patients whose breast tumors overexpress HER2 may derive particular benefit from… 
Highly Cited
2003
Highly Cited
2003
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction.
Highly Cited
2002
Highly Cited
2002
Targets of gene amplification and overexpression at 17q in gastric cancer.
DNA copy number gains and amplifications at 17q are frequent in gastriccancer, yet systematic analyses of the 17q amplicon have… 
Highly Cited
1999
Highly Cited
1999
Meiotic events at the centromeric heterochromatin: histone H3 phosphorylation, topoisomerase IIα localization and chromosome condensation
Mechanisms of chromosome condensation and segregation during the first meiotic division are not well understood. Resolution of… 
Highly Cited
1997
Highly Cited
1997
Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor
DNA topoisomerase II (topo II) is an essential nuclear enzyme involved in major cellular functions such as DNA replication… 
Highly Cited
1993
Highly Cited
1993
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.
A plasmid was constructed for the expression of human DNA topoisomerase II alpha in yeast from a galactose-inducible promoter of… 
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