DNA topoisomerase II alpha

Known as: DNA Topoisomerase II, Alpha Isozyme, EC 5.99.1.3, Topo II Alpha 
DNA topoisomerase 2-alpha (1531 aa, ~174 kDa) is encoded by the human TOP2A gene. This protein is involved in the modulation of DNA topology.

Topic mentions per year

Topic mentions per year

1986-2017
020406019862017

Papers overview

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Highly Cited
2014
Highly Cited
2014
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system for genome editing has greatly… (More)
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2000
2000
DNA topoisomerase II alpha is required for chromatin condensation during prophase. This process is temporally linked with the… (More)
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1999
1999
The transcription factor YB-1 is expressed in a wide range of cell types and has been implicated in the regulation of various… (More)
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Highly Cited
1999
Highly Cited
1999
Topoisomerase IIalpha (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs… (More)
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1997
1997
DNA topoisomerase II (topo II) is an essential nuclear enzyme involved in major cellular functions such as DNA replication… (More)
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1996
1996
DNA topoisomerase II is a nuclear enzyme essential for chromosome dynamics and DNA metabolism. In mammalian cells, two… (More)
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1996
1996
It has been suggested that casein kinase II phosphorylates DNA topoisomerase II alpha (topo II alpha) in mouse FM3A cells, by… (More)
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1995
1995
Increased expression of DNA topoisomerase II alpha has been associated with resistance to certain DNA-damaging alkylating agents… (More)
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1994
1994
For characterizing in vivo functions of a mammalian protein, it is informative to obtain conditional mutations and apply them to… (More)
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1993
1993
We have determined that the major mitotic phosphoprotein in chromosomes recognized by the antiphosphoprotein antibody MPM-2 is… (More)
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