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DNA topoisomerase II alpha
Known as:
DNA Topoisomerase II, Alpha Isozyme
, EC 5.99.1.3
, Topo II Alpha
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DNA topoisomerase 2-alpha (1531 aa, ~174 kDa) is encoded by the human TOP2A gene. This protein is involved in the modulation of DNA topology.
National Institutes of Health
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Related topics
Related topics
17 relations
5-chloroquinoxaline-2-sulfanilamide
ATPase Domain
Cell Nucleus
Chromosome Condensation
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Broader (3)
Antigens, Neoplasm
DNA-Binding Proteins
Topoisomerase II
Narrower (1)
TOP2A protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Mining hub genes associated with late stage adrenocortical carcinoma
Di Yu
,
Chen Dongshan
,
Yu Wei
,
Yan Lei
Biomedical research
2019
Corpus ID: 201964621
Background: Adrenocortical carcinoma (ACC) was in poor prognosis especially the late stages. Our research tried to discover…
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2018
2018
Abstract P2-10-06: Identifying patients sensitive to anthracycline-containing therapy with quantitative proteomic and genomic profiling
Sarit Schwartz
,
F. Cecchi
,
+9 authors
P. Fasching
2018
Corpus ID: 79879201
Background: Selecting chemotherapy based on tumor biology can improve response rates and avert toxicity. Studies of the…
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2016
2016
Abstract OT3-02-02: ROSCO: A randomised phase III, stratified CEP17/TOP2A biomarker trial of neo-adjuvant 5-flourouracil, epirubicin and cyclophosphamide vs docetaxel and cyclophosphamide…
D. Rea
,
L. Haywood
,
+14 authors
J. Bartlett
2016
Corpus ID: 77355914
Background: Patients with high risk early breast cancer undergoing chemotherapy are frequently treated with both anthracycline…
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2016
2016
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
Kevin Wu
2016
Corpus ID: 87169048
2013
2013
A chromatin remodeling complex regulates topoisomerase IIα function.
Cancer Discovery
2013
Corpus ID: 43919450
TOP2A-mediated DNA decatenation during mitosis requires the BAF subunits BRG1 and BAF250A.
2013
2013
Abstract PD4-1: Comparison of mutations and protein expression in potentially actionable targets in 5500 triple negative vs. non-triple negative breast cancers
J. O’Shaughnessy
,
Z. Gatalica
,
Jeff Kimbrough
,
S. Millis
2013
Corpus ID: 71413547
Introduction Triple negative breast cancer is a heterogeneous disease with no established targeted treatment options for…
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2013
2013
BRCA 1 AND TOP 2 A GENE AMPLIFICATION AND PROTEIN EXPRESSION IN FOUR MOLECULAR SUBTYPES OF BREAST CANCER
O. Mitrović
,
M. Mićić
,
+5 authors
Tijana Breković
2013
Corpus ID: 55957725
We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four…
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2011
2011
Hubungan Overekspresi Topoisomerase Il Alfa dengan Over-ekspresi Her-2/neu dan Berbagai Derajat Histologik Karsinoma Duktal Invasif Tidak Spesifik Payudara
Jane Kosasih
,
I. G. Artha
2011
Corpus ID: 117204689
ABSTRAK Latar Belakang Peranan enzim Topoisomerase II I± (TOP2A) sebagai faktor prognostik dan faktor prediktif terapi…
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2010
2010
Studies Ability of Biomarkers to Predict Systemic Progression en with High-Risk Prostate Cancer Treated R gically Is Dependent on ERG Status
frey Karnes
,
J. Cheville
,
+5 authors
G. Vasmatzis
2010
Corpus ID: 1957731
nloaded objective of this study was to assess the relationship of the tumor protein levels of TOP2A and MIB-1 RG status with…
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2008
2008
Investigating the predictive value of topoisomerase II alpha (TOP2A) gene, mRNA and protein levels in anthracycline-treated estrogen receptor (ER) negative breast cancer patients.
C. Desmedt
,
E. Azambuja
,
+7 authors
C. Sotiriou
2008
Corpus ID: 68396951
11065 Background: Anthracycline-based regimens are among the most active chemotherapies in BC. However, their clinical use is…
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