P. Morin

Publications122
h-index56
Citations25,027
Highly Influential Citations973
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • B. Vogelstein
  • 898 Publications • 347,284 Citations
  • K. Kinzler
  • 576 Publications • 209,255 Citations
  • I. Shih
  • 503 Publications • 38,651 Citations
  • H. Clevers
  • 998 Publications • 184,445 Citations
  • Publications
  • Influence
Identification of c-MYC as a target of the APC pathway.
TLDR
The c-MYC oncogene is identified as a target gene in this signaling pathway and shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c- MYC promoter.
View on PubMed
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
TLDR
Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
View on Publisher
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
TLDR
Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
View on Publisher
Claudin proteins in human cancer: promising new targets for diagnosis and therapy.
  • P. Morin
  • Medicine, Biology
    Cancer research
  • 1 November 2005
TLDR
The tight junction proteins claudins are abnormally regulated in several human cancers and represent promising targets for cancer detection, diagnosis, and therapy.
View on PubMed
Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer
TLDR
It is suggested that CTNNB1 mutations can uniquely substitute for APC mutations in CR tumors and that β-catenin signaling plays a critical role in CR tumorigenesis.
Apoptosis and APC in colorectal tumorigenesis.
TLDR
It is shown that expression of APC in human colorectal cancer cells containing endogenous inactive APC alleles results in a substantial diminution of cell growth, and that this was due to the induction of cell death through apoptosis.
View on PubMed
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.
TLDR
The results suggest that claudin overexpression may promote ovarian tumorigenesis and metastasis through increased invasion and survival of tumor cells, showing that malignant cells have alternative or additional pathways to fully activate MMP-2.
View on PubMed
An anatomy of normal and malignant gene expression
TLDR
An easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues, displayed on the SAGE Anatomic Viewer.
View on Publisher
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
TLDR
The results suggest that CTNNB1 mutations can uniquely substitute for APC mutations in CR tumors and that beta-catenin signaling plays a critical role in CR tumorigenesis.
View on PubMed
A public database for gene expression in human cancers.
A public database, SAGEmap, was created as a component of the Cancer Genome Anatomy Project to provide a central location for depositing, retrieving, and analyzing human gene expression data. This…
View on PubMed
...
...