• Publications
  • Influence
Identification of c-MYC as a target of the APC pathway.
The c-MYC oncogene is identified as a target gene in this signaling pathway and shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c- MYC promoter.
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
Claudin proteins in human cancer: promising new targets for diagnosis and therapy.
  • P. Morin
  • Medicine, Biology
    Cancer research
  • 1 November 2005
The tight junction proteins claudins are abnormally regulated in several human cancers and represent promising targets for cancer detection, diagnosis, and therapy.
Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer
It is suggested that CTNNB1 mutations can uniquely substitute for APC mutations in CR tumors and that β-catenin signaling plays a critical role in CR tumorigenesis.
Apoptosis and APC in colorectal tumorigenesis.
It is shown that expression of APC in human colorectal cancer cells containing endogenous inactive APC alleles results in a substantial diminution of cell growth, and that this was due to the induction of cell death through apoptosis.
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.
The results suggest that claudin overexpression may promote ovarian tumorigenesis and metastasis through increased invasion and survival of tumor cells, showing that malignant cells have alternative or additional pathways to fully activate MMP-2.
An anatomy of normal and malignant gene expression
An easily accessible view of nearly any gene's expression in a wide variety of malignant and normal tissues, displayed on the SAGE Anatomic Viewer.
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
The results suggest that CTNNB1 mutations can uniquely substitute for APC mutations in CR tumors and that beta-catenin signaling plays a critical role in CR tumorigenesis.
A public database for gene expression in human cancers.
A public database, SAGEmap, was created as a component of the Cancer Genome Anatomy Project to provide a central location for depositing, retrieving, and analyzing human gene expression data. This