Topoisomerase II

Known as: Type II DNA Topoisomerase, DNA Topoisomerases, Type II [Chemical/Ingredient], DNA topoisomerase II 
Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including… (More)
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Review
2009
Review
2009
DNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA. Many of these can be… (More)
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Highly Cited
2006
Highly Cited
2006
Multiple enzymatic activities are required for transcriptional initiation. The enzyme DNA topoisomerase II associates with gene… (More)
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Review
2005
Review
2005
Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. It has been in clinical… (More)
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Highly Cited
1997
Highly Cited
1997
Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand… (More)
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Highly Cited
1996
Highly Cited
1996
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large… (More)
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… (More)
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Highly Cited
1985
Highly Cited
1985
We have obtained a polyclonal antibody that recognizes a major polypeptide component of chicken mitotic chromosome scaffolds… (More)
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Highly Cited
1984
Highly Cited
1984
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the… (More)
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Highly Cited
1984
Highly Cited
1984
A temperature-sensitive DNA topoisomerase II mutant of the yeast Saccharomyces cerevisiae has been identified. Genetic analysis… (More)
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