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Topoisomerase II

Known as: Type II DNA Topoisomerase, DNA Topoisomerases, Type II [Chemical/Ingredient], DNA topoisomerase II 
Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The… 
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (5)

DNA GyraseDNA topoisomerase II alphaDNA topoisomerase II betaDNA topoisomerase VI
DNA ReplicationDNA topoisomerase type II activityEnzyme GeneIn Blood

Broader (1)

Isomerase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Dietary topoisomerase II-poisons : contribution of soy products to infant leukemia ?
DNA topoisomerases are nuclear enzymes inducing transient breaks in the DNA allowing DNA strands or double helices to pass… 
1997
1997
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Topoisomerase II is the cytotoxic target for a number of clinically relevant antineoplastic drugs. Despite the fact that these… 
1997
1997
Down-regulation of topoisomerase II by camptothecin does not prevent additive activity of the topoisomerase II inhibitor etoposide in vitro
Topoisomerases (Topo) I and II are cellular enzymes that catalyze the relaxation of topologically strained DNA and that are… 
1992
1992
Topoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histones
Based on the use of equilibrium centrifugation in CsCl to separate covalent complexes between topoisomerase I and DNA from… 
1991
1991
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin.
Terpentecin and clerocidin, microbial terpenoides, have been known to be potent antitumor antibiotics. However, the critical… 
1987
1987
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.
A human Burkitt's lymphoma cell line (Raji-HN2) made resistant to nitrogen mustard, a bifunctional alkylating agent, was used to… 
1986
1986
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
It has been reported that the action of etoposide (VP-16) (14) as an antitumor agent is mediated through its interaction with DNA… 
1985
1985
Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide in L1210 murine…
Treatment of mouse leukemia L1210 cells with the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) increased… 
1984
1984
A protein kinase activity tightly associated with Drosophila type II DNA topoisomerase.
A protein kinase activity has been identified that is tightly associated with the purified Drosophila type II DNA topoisomerase… 
1983
1983
Inhibition of Micrococcus luteus DNA topoisomerase I by UV photoproducts.
The activity of Micrococcus luteus DNA topoisomerase I on UV-irradiated supercoiled DNA was studied under either processive or…