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Topoisomerase II

Known as: Type II DNA Topoisomerase, DNA Topoisomerases, Type II [Chemical/Ingredient], DNA topoisomerase II 
Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Canonical DNA non-homologous end-joining (c-NHEJ) and homologous recombination (HR), the two major DNA double-strand break (DSB… Expand
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Review
2018
Review
2018
DNA gyrase is classified as topoisomerase II, an ATP-dependent enzyme that is vital in the transcription, replication of DNA and… Expand
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Review
2009
Review
2009
  • J. Nitiss
  • Nature Reviews Cancer
  • 2009
  • Corpus ID: 20536106
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including… Expand
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Highly Cited
1997
Highly Cited
1997
Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand… Expand
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Highly Cited
1996
Highly Cited
1996
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large… Expand
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Review
1989
Review
1989
  • L. Liu
  • Annual review of biochemistry
  • 1989
  • Corpus ID: 45124651
PERSPECTIVES AND SUMMARY .. . . ...... . ... 351 MAMMALIAN DNA TOPOISOMERASES… Expand
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Highly Cited
1985
Highly Cited
1985
We have obtained a polyclonal antibody that recognizes a major polypeptide component of chicken mitotic chromosome scaffolds… Expand
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Highly Cited
1985
Highly Cited
1985
We have constructed five new temperature-sensitive DNA topoisomerase II mutations and have analyzed their physiological… Expand
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Highly Cited
1984
Highly Cited
1984
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the… Expand
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Highly Cited
1984
Highly Cited
1984
Many intercalative antitumor drugs have been shown to cleave DNA indirectly through their specific effect on the stabilization of… Expand
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