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Hypoxia and radiation therapy: past history, ongoing research, and future promise.
TLDR
The importance of new technologies for measuring Hypoxia in human tumors, which allow assessment of pretreatment tumor oxygen levels and changes in hypoxia over the course of prolonged treatment regimens, are described and the importance of improved understanding of the abnormal vascular beds in solid tumors is discussed. Expand
Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
TLDR
The findings suggest that NADPH:cytochrome c reductase and some as yet to be identified enzyme(s) are important for the reductive activation of MC, which is presumably responsible for the observed cytotoxicity. Expand
Genetic instability induced by the tumor microenvironment.
TLDR
The results indicate that the conditions within solid tumors are mutagenic and suggest that a fundamental mechanism of tumor progression in vivo is genetic instability induced by the tumor microenvironment. Expand
Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data.
TLDR
Findings indicate that hypoxic cells are a common feature of solid tumors in rodents and provide no evidence that Hypoxic cells should not be present in human tumors. Expand
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents
TLDR
The findings suggest that SF-mediated protection of human breast cancer cells may involve inhibition of one or more pathways required for the activation of apoptosis and may particularly target the anti-apoptotic mitochondrial membrane pore-forming protein Bcl-XL as a component of the protective mechanism. Expand
Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.
TLDR
Bioreductive alkylating agents like mitomycin C have the potential to attack selectively the chemotherapeutically resistant hypoxic cell component of solid tumors and should be useful adjuncts to existing therapeutic regimens which are effective against well-oxygenated cells. Expand
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.
TLDR
A potential new pathway of genetic instability in cancer is identified: hypoxia-induced reduction in the expression of key MMR proteins, which may represent a conceptual parallel to the pathway of stationary-phase mutagenesis seen in bacteria. Expand
Priority List of Research Areas for Radiological Nuclear Threat Countermeasures
TLDR
The research areas that the committee felt required the attention of the radiation research community are described in this report in an effort to inform this community about the needs of the nation and to encourage researchers to address these critical issues. Expand
Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells
TLDR
A potential new pathway of genetic instability in cancer is identified: hypoxia-induced reduction in the expression of key MMR proteins, which may represent a conceptual parallel to the pathway of stationary-phase mutagenesis seen in bacteria. Expand
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