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Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.
  • S. Young, F. Qing, +6 authors R. Miller
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 June 1996
Gadolinium(III) texaphyrin (Gd-tex2+) was found to be an efficient radiation sensitizer in studies carried out with HT29 cells in in vitro as well as in in vivo single and multifraction irradiation studies with a murine mammary carcinoma model. Expand
Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species.
Gd-Tex sensitizes cells to ionizing radiation by increasing oxidative stress as a consequence of futile redox cycling and optimization of the concentration of ascorbate (or other reducing species) may be required when evaluating Gd- Tex activity in vitro. Expand
Lutetium Texaphyrin (PCI‐0123): A Near‐Infrared, Water‐Soluble Photosensitizer
Lutetium texaphyrin macrocycle as illustrated by magnetic resonance imaging and 14C‐radiolabeled texphyrin studies was shown to be tumor selective; a tumor‐to‐muscle ratio of 10.55 was seen after 5 h. Expand
Texaphyrins: new drugs with diverse clinical applications in radiation and photodynamic therapy.
Taken in concert, these two metallotexaphyrins provide a powerful new class of experimental drugs whose diverse potential utility is abetted by a combination of well-optimized physical features, favorable tissue biolocalization characteristics, and novel mechanisms of action. Expand
In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer.
Gd-Tex produces reproducible radiation enhancement in a variety of in vivo tumor models and suggests possible mechanisms of action not addressed by in vitro assay methods. Expand
Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules.
An overview of the design principles underlying small fluorescent probes that have been applied to the ratiometric detection of various analytes, including cations, anions, and biomolecules in solution and in biological samples are provided. Expand
6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling
The current results suggest that 6-SHO may have potential as a chemopreventive and/or therapeutic agent for prostate cancer and that further study of this compound is warranted. Expand
Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex: A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging
Gadolinium (III) texaphyrin complex appears to be an effective and safe MRI contrast agent. Expand
Reagentless, Ratiometric Electrochemical DNA Sensors with Improved Robustness and Reproducibility
To make the electrochemical DNA sensors (E-sensor) more robust and reproducible, the techniques of ratiometric analyses to the field of E-sensors are adapted via the simple expedient way of simultaneously using two redox probes: methylene blue as the reporter of the conformational change, and ferrocene as an internal control. Expand
Enhanced anion exchange for selective sulfate extraction: overcoming the Hofmeister bias.
The present work provides a rare demonstration of overcoming the Hofmeister bias in a competitive environment and the first to the authors' knowledge wherein this difficult-to-achieve objective is attained using a neutral HBD-based anion binding agent under conditions of solvent extraction. Expand