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Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
TLDR
WBRT and stereotactic radiosurgery should, therefore, be standard treatment for patients with a single unresectable brain metastasis and considered for Patients with two or three brain metastases. Expand
A randomized trial of bevacizumab for newly diagnosed glioblastoma.
TLDR
First-line use of bevacizumab did not improve overall survival in patients with newly diagnosed glioblastoma, and progression-free survival was prolonged but did not reach the prespecified improvement target. Expand
A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database.
TLDR
The new index, the GPA, is as prognostic as the RPA and more prognostic than the other indices and is the least subjective, most quantitative and easiest to use of the four indices. Expand
Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases.
TLDR
These indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases. Expand
Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.
TLDR
For patients with AO and AOA, PCVplus RT does not prolong survival, and longer progression-free survival after PCV plus RT is associated with significant toxicity. Expand
Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients.
TLDR
The prognostic factors for BM patients varied by diagnosis, and two new DS-GPA indexes were designed for breast/gastrointestinal cancer and melanoma/renal cell carcinoma. Expand
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.
TLDR
The data supporting MGMT as a major mechanism of chemotherapy resistance in malignant gliomas is reviewed and ongoing studies that are testing resistance-modulating strategies are described. Expand
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
TLDR
For the subset of patients with 1p/19q codeleted AO/AOA, PCV plus RT may be an especially effective treatment, although this observation was derived from an unplanned analysis. Expand
Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model.
TLDR
The MSKCC prognostic score is a simple, statistically powerful model with universal applicability to patients with newly diagnosed PCNSL and is recommended that it be adopted for the management of newly diagnosed patients and incorporated into the design of prospective clinical trials. Expand
Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial.
TLDR
Conformal avoidance of the hippocampus during WBRT is associated with preservation of memory and QOL as compared with historical series. Expand
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