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Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.
- J. Carmichael, W. Degraff, A. Gazdar, J. Minna, J. Mitchell
- Biology, MedicineCancer research
- 15 February 1987
The clonogenic assay was more sensitive when continuous drug exposures were utilized, although this was primarily related to the increased drug exposure time, and therefore it offers a valid, simple method of assessing chemosensitivity in established cell lines.
Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity.
While optimal conditions for each cell line (cell number plated and doubling time) must be established, the 3-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay could be automated and thus be of great value in screening large numbers of potential radiosensitizers or protectors.
The multifaceted roles of nitric oxide in cancer.
- D. Wink, Y. Vodovotz, J. Laval, F. Laval, M. Dewhirst, J. Mitchell
- Chemistry, BiologyCarcinogenesis
- 1 May 1998
How the chemistry of NO may impact the initiation and progression stages of cancer is discussed.
Viability measurements in mammalian cell systems.
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.
- M. Krishna, D. Grahame, A. Samuni, J. Mitchell, A. Russo
- ChemistryProceedings of the National Academy of Sciences…
- 15 June 1992
The results indicate that the dismutation of .O2- is catalyzed by the oxoammonium/nitroxide redox couple for carbocyclic nitroxide derivatives, and suggest the possibility that cellular bioreduction by a two-electron pathway may occur subsequent to oxidation of stable nitroxides.
Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.
- D. Wink, I. Hanbauer, M. Krishna, W. DeGraff, J. Gamson, J. Mitchell
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1993
In the presence of NO released from (C2H5)2N[N(O)NO]-Na+ (DEA/NO), the cytotoxicity resulting from superoxide or hydrogen peroxide was markedly abrogated and this peroxide-mediated cytotoxic effect on mesencephalic cells was abolished.
Nitric oxide (NO) protects against cellular damage by reactive oxygen species.
Tempol, a stable free radical, is a novel murine radiation protector.
Tempol represents a new class of in vivo, non-sulfur-containing radiation protectors and has the potential for hypoxic radiosensitization and aerobic cell radioprotection, and Temporal or other analogues may have potential therapeutic application.
Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines.
- J. Liebmann, J. Cook, C. Lipschultz, D. Teague, J. Fisher, J. Mitchell
- Biology, MedicineBritish Journal of Cancer
- 1 December 1993
It appears that modest concentrations (i.e., 50 nM) should be as effective as higher concentrations of paclitaxel, while Cremophor EL is a biologically active diluent and, at high concentrations, can antagonise pac litaxel cytotoxicity.