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mitomycin A

Known as: Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester) 
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

MitomycinMitomycins
mitomycin B

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Design and synthesis of new mitomycin dimers containing a seven-membered cyclic disulfide and a diol linkers
We report the design and synthesis of two new mitomycin dimers, 7-N,7′-N′-(1″,2″-dithiepanyl-3″,7″-dimethylenyl)bismitomycin C (8… 
2007
2007
Analysis of a Parallel Branch in the Mitomycin Biosynthetic Pathway Involving the mitN-Encoded Aziridine N-Methyltransferase*
Mitomycin C is a natural product with potent alkylating activity, and it is an important anticancer drug and antibiotic. mitN… 
1995
1995
Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C.
Mitomycin C (MC), mitomycin A, porfiromycin, BMY-25067, and BMY-25287, antitumor antibiotics collectively termed "mitosanes… 
1991
1991
Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential.
The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA… 
Review
1989
Review
1989
Structure-activity comparison of mitomycin C and mitomycin A analogues (review).
Over 600 analogues of mitomycin C (MMC) have been made in the past and more recently a number of Mitomycin A (MMA) derivatives… 
1986
1986
A systematic study on the chemical stability of mitomycin A and mitomycin B.
The kinetics and mechanisms of the degradation of mitomycin A and mitomycin B in aqueous solution were investigated by means of… 
1985
1985
Qualitative aspects of the degradation of mitomycins in alkaline solution.
1983
1983
Specificity of antisera produced against mitomycin C.
The specificity of antisera produced in rabbits for use in mitomycin C (MMC) enzyme immunoassay has been examined employing… 
1981
1981
Development of new mitomycin C and porfiromycin analogues.
New mitomycin C and porfiromycin analogues were prepared by treating mitomycin A and N-methylmitomycin A with a variety of amines… 
1977
1977
Mitomycin antibiotics. Synthesis and activity of 1,2-disubstituted mitosenes.
cis-1-Acetamido-2-acetoxy-7-methoxy-N-methylmitosene was prepared in 11 steps from 7-methoxy-6-methyl-2,3-dihydro-1H-pyrrolo[1,2… 
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