mitomycin A

Known as: Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester) 
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates… (More)
National Institutes of Health

Papers overview

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2013
2013
The anticancer drug mitomycin C produces cytotoxic effects after being converted to a highly reactive bis-electrophile by a… (More)
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2007
2007
Mitomycin C is a natural product with potent alkylating activity, and it is an important anticancer drug and antibiotic. mitN… (More)
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2001
2001
Mitomycin A (MA) but not mitomycin C (MC) cross-linked linearized (32)P-pBR322 DNA in the presence of dithiothreitol (DTT) or… (More)
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1995
1995
Mitomycin C (MC), mitomycin A, porfiromycin, BMY-25067, and BMY-25287, antitumor antibiotics collectively termed "mitosanes… (More)
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1994
1994
The metabolisms of two standard electron acceptors and a series of bioreductive antitumor compounds by purified rat and human DT… (More)
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1992
1992
SummaryThe alkylating antitumor agents mitomycin A (MMA), mitomycin C (MMC), and sevenN7 analogs were compared in terms of their… (More)
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1991
1991
A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human… (More)
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1991
1991
The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA… (More)
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1983
1983
The specificity of antisera produced in rabbits for use in mitomycin C (MMC) enzyme immunoassay has been examined employing… (More)
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1981
1981
New mitomycin C and porfiromycin analogues were prepared by treating mitomycin A and N-methylmitomycin A with a variety of amines… (More)
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