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mitomycin A

Known as: Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester) 
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates… 
National Institutes of Health

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3 relations

Broader (2)

MitomycinMitomycins
mitomycin B

Papers overview

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2006
2006
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NEW DIMERIC MITOMYCIN DERIVATIVES; 7-NJ-N'-BIS(co-
The reaction between mitomycin A (1) and cysteamine afforded 7-7V,7'-7V'-bis(2-thioethyl)dimitomycin C (7), 7-Ar-[2-[(2… 
2002
2002
[Cloning of the replication origin (oriC) of Streptoverticillum caespitosus and transformation of Streptomyces lividans ZX7].
Streptoverticillum caespitosus ATCC27422 is a producing strain of mitomycin A for cancer therapy. Taking the advantage of the… 
1987
1987
Preparation and antitumor activity of new mitomycin A analogues.
A series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods. The most useful methods were… 
1986
1986
A systematic study on the chemical stability of mitomycin A and mitomycin B.
The kinetics and mechanisms of the degradation of mitomycin A and mitomycin B in aqueous solution were investigated by means of… 
1983
1983
Specificity of antisera produced against mitomycin C.
The specificity of antisera produced in rabbits for use in mitomycin C (MMC) enzyme immunoassay has been examined employing… 
1981
1981
Development of new mitomycin C and porfiromycin analogues.
New mitomycin C and porfiromycin analogues were prepared by treating mitomycin A and N-methylmitomycin A with a variety of amines… 
1980
1980
Verslag van de ‘20th Annual Meeting of the American Society of Pharmacognosy’, gehouden van 29 juli tot 3 augustus 1979 in de Purdue University, West-Lafayette, Indiana, USA
Het thema van deze bijeenkomst was 'Recent advances in antibiotics and alkaloids'. De eerste twee dagen van dit congres waren… 
1977
1977
Mitomycin antibiotics. Synthesis and activity of 1,2-disubstituted mitosenes.
cis-1-Acetamido-2-acetoxy-7-methoxy-N-methylmitosene was prepared in 11 steps from 7-methoxy-6-methyl-2,3-dihydro-1H-pyrrolo[1,2… 
1977
1977
Comparative stereochemistry in the aziridine ring openings of N-methylmitomycin A and 7-methoxy-1,2-(N-methylaziridino)mitosene.
A useful method was found for the conversion of mitomycin C into N-methylmitomycin A. The latter compound gave only two products… 
1969
1969
Veränderungen des Aminosäurepools bei multiplen Myelomen
ZusammenfassungMehrfache Analysen der freien Aminosäuren im Plasma bei 12 Patienten mit multiplen Myelomen ergaben, daß jedes…