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mitomycin B

Known as: Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-8-(hydroxymethyl)-6-methoxy-1,5-dimethyl-, 8-carbamate 
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin B generates… 
National Institutes of Health

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Broader (1)

Mitomycin
mitomycin A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Hydroxyquinone O-methylation in mitomycin biosynthesis.
Mitomycins are bioreductively activated DNA-alkylating agents. One member of this family, mitomycin C, is in clinical use as part… 
2004
2004
Mitomycins and the bleaching of Euglena gracilis
SummaryThe effects of some mitomycin antibiotics on the chloroplast system of Euglena gracilis were studied. Only those… 
1991
1991
The configuration of mitiromycin and its derivation from mitomycin B.
The configuration of mitiromycin (2) was first determined by NMR experiments including the NOE technique. The absolute structure… 
1988
1988
Precursors in the biosynthesis of FR-900482, a novel antitumor antibiotic produced by Streptomyces sandaensis.
isolated from the culture broth of Streptomyces sandaensis No. 6897, was found to have unique structure1*^. FR-900482 differs… 
1986
1986
A systematic study on the chemical stability of mitomycin A and mitomycin B.
The kinetics and mechanisms of the degradation of mitomycin A and mitomycin B in aqueous solution were investigated by means of… 
1986
1986
New mitomycin analogs produced by directed biosynthesis.
When the normal fermentation medium for the production of mitomycin C with Streptomyces caespitosus is supplemented with a number… 
1985
1985
Lack of influence of the carbamoyl group on the stereochemistry of the acid-catalyzed opening of the aziridine ring of the mitomycins and of congeners.
The acid-catalyzed opening of the aziridine ring of mitomycins A and C is known to occur predominantly with cis stereochemistry… 
1981
1981
Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin B and its analogs.
A new naturally occurring mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B (1), was prepared by treating mitomycin B with sodium… 
Highly Cited
1978
Highly Cited
1978
Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping.
The reduced antitumor antibiotic mitomycin C in aqueous solution exposed to air gives a 36-line electron spin resonance spectrum… 
1978
1978
Studies related to antitumor antibiotics. Part XIV. Reactions of mitomycin B with DNA.
The reactions of the antitumor antibiotic mitomycin B with DNA were examined using ethidium fluorescence assays. The following… 
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