Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin B and its analogs.

@article{Urakawa1981PreparationAB,
  title={Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin B and its analogs.},
  author={C. Urakawa and H. Tsuchiya and K. Nakano and N. Nakamura},
  journal={The Journal of antibiotics},
  year={1981},
  volume={34 9},
  pages={
          1152-6
        }
}
  • C. Urakawa, H. Tsuchiya, +1 author N. Nakamura
  • Published 1981
  • Chemistry, Medicine
  • The Journal of antibiotics
  • A new naturally occurring mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B (1), was prepared by treating mitomycin B with sodium hydride. Its analogs having an exo-cyclic double bond in their structure were also synthesized. These compounds showed antibacterial and cytotoxic activities. Among them, 7-amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B (2) was the most potent growth inhibitor of KB cells in vitro and, accordingly, it appears to be a potential antitumor agent. 
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