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The chemistry of antitumor antibiotics
Streptozocin. Pyrrolo (1,4) Benzodiazepines. Saframycins, Renieramycins, and Safracins. Naphthyridinomycin, Cyanocyclines, and Quinocarcin. CC-1065. Nogalamycin and Related Compounds. StreptonigrinExpand
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6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity
New 2-[2'-(dimethylamino)ethyl]-3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at the 6- and 7-positions were prepared. Nucleophilic aromatic displacement was a key reaction in theExpand
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Analogues of amonafide and azonafide with novel ring systems.
Three new types of amonafide and azonafide analogues were synthesized and screened in a panel of human solid tumor cells and murine L1210 leukemia cells. The structural types includedExpand
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Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Sets of 2-[2-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones with amino and actylamino groups at each of the eight positions on the anthracene nucleus were synthesized fromExpand
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Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators
The azonafides are a series of anthracene-based DNA intercalators which inhibit tumor cell growth in vitro at low nanomolar concentrations and are not affected by the multidrug resistance phenomenonExpand
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Computer simulation of the binding of quinocarcin to DNA. Prediction of mode of action and absolute configuration
TLDR
Computer-based models were derived for the covalent and noncovalent binding of the antitumor antibiotic quinocarcin to a representative DNA segment, d(ATGCAT)2. Expand
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Structure-activity comparison of mitomycin C and mitomycin A analogues (review).
Over 600 analogues of mitomycin C (MMC) have been made in the past and more recently a number of Mitomycin A (MMA) derivatives have been prepared. Since many of the MMA type had the same organic sideExpand
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1,4-disubstituted anthracene antitumor agents.
Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes.Expand
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