meropenem

Known as: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(3S*,5S*),4alpha,5beta,6beta(R*)))-, meropenem [Chemical/Ingredient], 3-(5-dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid 
A broad-spectrum carbapenem with antibacterial properties, synthetic Meropenem inhibits cell wall synthesis in gram-positive and gram-negative… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CONTEXT Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of… (More)
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Highly Cited
2011
Highly Cited
2011
Enterobacteriaceae producing carbapenemases, such as KPC or metallo-β-lactamases (MBLs), have emerged on several continents… (More)
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Highly Cited
2009
Highly Cited
2009
beta-lactam antibiotics are ineffective against Mycobacterium tuberculosis, being rapidly hydrolyzed by the chromosomally encoded… (More)
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Review
2009
Review
2009
From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae carbapenemases (KPC) were reported in the USA and… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVES To compare the plasma and subcutaneous tissue concentration-time profiles of meropenem administered by intermittent… (More)
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Highly Cited
2007
Highly Cited
2007
Studies of beta-lactam pharmacodynamics in infected patients are sparse. In this study, classification and regression tree (CART… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND It is known that beta-lactam antibiotics exhibit time-dependent bactericidal activity. Several studies have found… (More)
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Highly Cited
2005
Highly Cited
2005
Suppression of resistance in a dense Pseudomonas aeruginosa population has previously been shown with optimized quinolone… (More)
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Highly Cited
2001
Highly Cited
2001
A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The MICs of… (More)
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Highly Cited
1992
Highly Cited
1992
Multiple-drug-resistant mutants were isolated from Pseudomonas aeruginosa PAO1 on agar plates containing ofloxacin and cefsulodin… (More)
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