Share This Author
Hepatitis B e antigen and the risk of hepatocellular carcinoma.
- Hwai I. Yang, Sheng-Nan Lu, Chien-Jen Chen
- Medicine, BiologyNew England Journal of Medicine
- 18 July 2002
Positivity for HBeAg is associated with an increased risk of hepatocellular carcinoma, and after adjustment for age, sex, the presence or absence of antibodies against hepatitis C virus, cigarette-smoking status, and use or nonuse of alcohol, the relative risk was 9.6%.
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Association between body-mass index and risk of death in more than 1 million Asians.
Underweight was associated with a substantially increased risk of death in all Asian populations, however, the excess risk of died was seen among East Asians but not among Indians and Bangladeshis.
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants
Predicting cirrhosis risk based on the level of circulating hepatitis B viral load.
- U. Iloeje, Hwai I. Yang, Jun Su, C. Jen, S. You, Chien-Jen Chen
- Medicine, BiologyGastroenterology
- 1 March 2006
The data show that progression to cirrhosis in hepatitis B-infected persons is correlated strongly with the level of circulating virus and is independent of hepatitis B e-antigen status and serum alanine transaminase level.
Epidemiological characteristics and risk factors of hepatocellular carcinoma
- Chien-Jen Chen, M. Yu, Y. Liaw
- Biology, MedicineJournal of gastroenterology and hepatology
- 1 October 1997
Recent molecular epidemiological studies have shown that low serum retinol levels as well as elevated serum levels of testosterone, neu oncoprotein and aflatoxin B1‐albumin adduct are associated with an increased HCC risk, and there is a synergistic interaction on HCC between chronic HBV infection and a flatoxin exposure.
Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma
- Hwai I. Yang, S. Yeh, Chien-Jen Chen
- Biology, MedicineJournal of the National Cancer Institute
- 20 August 2008
HBV genotype C and specific alleles of BCP and precore were associated with risk of HCC, and these associations were independent of serum HBV DNA level.
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants
Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men.
- M. Yu, S. Yeh, Chien-Jen Chen
- Medicine, BiologyJournal of the National Cancer Institute
- 16 February 2005
Measurements of HBV viral load and genotype may help to define which male HBV carriers aged 30 years or older are at high risk for HCC.