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Drug interactions with lipid‐lowering drugs: Mechanisms and clinical relevance
Gemfibrozil greatly increases plasma concentrations of cerivastatin
- J. Backman, C. Kyrklund, M. Neuvonen, P. Neuvonen
- Medicine, BiologyClinical pharmacology and therapeutics
- 1 December 2002
The effect of gemfibrozil on cerivastatin pharmacokinetics was studied to study the mechanism of this potentially fatal drug interaction.
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide
Gemfibrozil alone and in combination with itraconazole considerably enhanced and prolonged the blood glucose-lowering effect of repaglinide; i.e., repaglinside became a long-acting and stronger antidiabetic.
Polymorphic Organic Anion Transporting Polypeptide 1B1 is a Major Determinant of Repaglinide Pharmacokinetics
Cyclosporine markedly raises the plasma concentrations of repaglinide
Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.
- L. Kajosaari, J. Laitila, P. Neuvonen, J. Backman
- Biology, ChemistryBasic & clinical pharmacology & toxicology
- 1 October 2005
Both CYP2C8 and CYP3A4 are important in the metabolism of therapeutic concentrations of repaglinide in vitro, but their predicted contributions in vivo are highly dependent on the scaling factor used.
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).
This study aimed to characterize possible relationships between polymorphisms in the drug transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (SLCO2B1), multidrug…
Dose of midazolam should be reduced during diltiazem and verapamil treatments.
- J. Backman, K. Olkkola, K. Aranko, J. Himberg, P. Neuvonen
- Medicine, BiologyBritish journal of clinical pharmacology
- 1 March 1994
If the administration of midazolam cannot be avoided, the dose of midAZolam should be reduced during concomitant treatment with diltiazem and verapamil, as these changes in the pharmacokinetics were associated with profound and prolonged sedative effects.
The area under the plasma concentration–time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin
- J. Backman, K. Kivistö, K. Olkkola, P. Neuvonen
- Biology, MedicineEuropean Journal of Clinical Pharmacology
- 1 March 1998
Switching from inhibition to induction of cytochrome P450 3A (CYP3A) enzymes causes a very great change in the AUC of oral midazolam, which is greatly decreased by itraconazole and increased by rifampicin.
Gemfibrozil considerably increases the plasma concentrations of rosiglitazone
- M. Niemi, J. Backman, M. Granfors, J. Laitila, M. Neuvonen, P. Neuvonen
- Medicine, ChemistryDiabetologia
- 29 July 2003
Co-administration of gemfibrozil, or another potent inhibitor of CYP2C8, and rosiglitazone could increase the efficacy but also the risk of concentration-dependent adverse effects of rosigsig litazone.