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irinotecan

Known as: (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate, Irrinotecan, (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a… 
National Institutes of Health

Papers overview

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Review
2009
Review
2009
PURPOSE We evaluated the efficacy of bevacizumab, alone and in combination with irinotecan, in patients with recurrent… 
Highly Cited
2009
Highly Cited
2009
  • T. Kreisl, L. Kim, H. Fine
  • Journal of clinical oncology : official journal…
  • 2009
  • Corpus ID: 9595452
PURPOSE To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma. PATIENTS AND METHODS Patients… 
Highly Cited
2007
Highly Cited
2007
PURPOSE The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months. We… 
Highly Cited
2007
Highly Cited
2007
PURPOSE The Gruppo Oncologico Nord Ovest (GONO) conducted a phase III study comparing fluorouracil, leucovorin, oxaliplatin, and… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND The epidermal growth factor receptor (EGFR), which participates in signaling pathways that are deregulated in cancer… 
Highly Cited
2004
Highly Cited
2004
PURPOSE Three agents with differing mechanisms of action are available for treatment of advanced colorectal cancer: fluorouracil… 
Highly Cited
2000
Highly Cited
2000
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal…