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irinotecan

Known as: (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate, Irrinotecan, (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Importance Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant… Expand
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Review
2017
Review
2017
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer… Expand
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Highly Cited
2007
Highly Cited
2007
PURPOSE The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months. We… Expand
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Highly Cited
2006
Highly Cited
2004
Highly Cited
2004
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The epidermal growth factor receptor (EGFR), which participates in signaling pathways that are deregulated in cancer… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE Three agents with differing mechanisms of action are available for treatment of advanced colorectal cancer: fluorouracil… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND In phase II studies, irinotecan is active in metastatic colorectal cancer, but the overall benefit has not been… Expand
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