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irinotecan

Known as: (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate, Irrinotecan, (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a… 
National Institutes of Health

Related topics

Related topics

35 relations
10 ML irinotecan hydrochloride liposome 4.3 MG/ML Injection [Onivyde]7-ethyl-10-hydroxycamptothecinApoptosisCYP3A7 protein, human

Broader (6)

Antineoplastic AgentsAntineoplastic Agents, PhytogenicCamptothecinEnzyme Inhibitors

Narrower (2)

CamptosarNK012 compound

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial.
Highly Cited
2008
Highly Cited
2008
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
PurposeThe pathobiology of alimentary tract (AT) mucositis is complex and there is limited information about the events which… 
Highly Cited
2007
Highly Cited
2007
Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
The safety and efficacy of the fully human antibody panitumumab was evaluated in patients with metastatic colorectal cancer… 
Highly Cited
2007
Highly Cited
2007
Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan.
PURPOSE In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of… 
Highly Cited
2006
Highly Cited
2006
Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience.
Highly Cited
2006
Highly Cited
2006
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
Review
2006
Review
2006
MDR- and CYP3A4-mediated drug-herbal interactions.
Highly Cited
2003
Highly Cited
2003
Irinotecan pathway genotype analysis to predict pharmacokinetics.
PURPOSE The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for… 
Review
2001
Review
2001
Irinotecan in the treatment of colorectal cancer: clinical overview.
PURPOSE AND METHODS For more than three decades, the therapeutic options for patients with advanced colorectal cancer have almost… 
Review
1998
Review
1998
Oxaliplatin: a review of preclinical and clinical studies.
Of the new generation platinum compounds that have been evaluated, those with the 1,2-diaminocyclohexane carrier ligand-including… 
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