irinotecan

Known as: (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate, Irrinotecan, (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
PURPOSE The addition of cetuximab to irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Panitumumab is a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody that improves progression… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma. PATIENTS AND METHODS Patients… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To determine whether adding cetuximab to irinotecan prolongs survival in patients with metastatic colorectal cancer (mCRC… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months. We… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE The Gruppo Oncologico Nord Ovest (GONO) conducted a phase III study comparing fluorouracil, leucovorin, oxaliplatin, and… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Three agents with differing mechanisms of action are available for treatment of advanced colorectal cancer: fluorouracil… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We… (More)
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